Neutralizing the Free Radicals Could Alleviate the Disease Severity Following an Infection by Positive Strand RNA Viruses

Overview

Journal Cell Stress Chaperones

Publisher Elsevier

Specialty Cell Biology

Date 2022 Apr 3

PMID 35366756

Authors

Agieshkumar Balakrishna Pillai

Aashika Raagavi JeanPierre

Vignesh Mariappan

Pajanivel Ranganadin

Rao S R

Affiliations

Soon will be listed here.

Abstract

Free radical release due to oxidative stress is gaining importance in the field of viral pathogenesis. Recent studies suggest the involvement of oxidative stress and ROS levels in regulating disease virulence during RNA virus infection. Most of the RNA virus infections lead to vascular dysfunction and disease severity. However, the biology of free radicals in maintaining vascular endothelium integrity is not completely understood. In the present review, we discuss some of the common features in positive-strand RNA virus infections such as dengue and SARS-CoV-2 and suggest that anti-oxidant therapy could pave the way to develop therapeutic strategies in combating emerging and re-emerging RNA viruses.

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