[Role of Circular RNAs in Immune-related Diseases]

Overview

Journal Nan Fang Yi Ke Da Xue Xue Bao

Specialty General Medicine

Date 2022 Apr 2

PMID 35365439

Authors

Weijie Zhan

Tao Yan

Jiawen Gao

Minkai Song

Ting Wang

Fei Lin

Haiyu Zhou

Li Li

Chao Zhang

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are non-coding RNAs (ncRNA) circularized without a 3' polyadenylation [poly-(A)] tail or a 5' cap, resulting in a covalently closed loop structure. circRNAs were first discovered in RNA viruses in the 1970s, but only a small number of circRNAs were discovered at that time due to limitations in traditional polyadenylated transcriptome analyses. With the development of specific biochemical and computational methods, recent studies have shown the presence of abundant circRNAs in eukaryotic transcriptomes. circRNAs play vital roles in many physiological and pathological processes, such as acting as miRNA sponges, binding to RNA-binding proteins (RBPs), acting as transcriptional regulatory factors, and even serving as translation templates. Current evidence has shown that circRNAs can be potentially used as excellent biomarkers for diagnosis, therapeutic effect evaluation, and prognostic assessment of a variety of diseases, and they may also provide effective therapeutic targets due to their stability and tissue and development-stage specificity. This review focuses on the properties of circRNAs and their immune relationship to disease, and explores the role of circRNAs in immune-related diseases and the directions of future research.

Citing Articles

Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis.

Chao Y, Jin X, Guo R, Zhang H, Cui X, Qi Y J Inflamm Res. 2024; 17:8487-8500.

PMID: 39534060 PMC: 11556230. DOI: 10.2147/JIR.S472213.

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