The 14-3-3 Protein Family and Schizophrenia
Overview
Authors
Affiliations
Schizophrenia is a debilitating mental disorder that affects approximately 1% of the world population, yet the disorder is not very well understood. The genetics of schizophrenia is very heterogenous, making it hard to pinpoint specific alterations that may cause the disorder. However, there is growing evidence from human studies suggesting a link between alterations in the 14-3-3 family and schizophrenia. The 14-3-3 proteins are abundantly expressed in the brain and are involved in many important cellular processes. Knockout of 14-3-3 proteins in mice has been shown to cause molecular, structural, and behavioral alterations associated with schizophrenia. Thus, 14-3-3 animal models allow for further exploration of the relationship between 14-3-3 and schizophrenia as well as the study of schizophrenia pathology. This review considers evidence from both human and animal model studies that implicate the 14-3-3 family in schizophrenia. In addition, possible mechanisms by which alterations in 14-3-3 proteins may contribute to schizophrenia-like phenotypes such as dopaminergic, glutamatergic, and cytoskeletal dysregulations are discussed.
Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction.
Andlovic B, Valenti D, Centorrino F, Picarazzi F, Hristeva S, Hiltmann M Biochemistry. 2024; 63(17):2196-2206.
PMID: 39172504 PMC: 11375770. DOI: 10.1021/acs.biochem.4c00248.
Zhao Y, Chen Y, Guo C, Li P, Cheng Z, Zheng L Theranostics. 2024; 14(9):3653-3673.
PMID: 38948066 PMC: 11209716. DOI: 10.7150/thno.92676.
Modulating GPCR and 14-3-3 protein interactions: Prospects for CNS drug discovery.
Kongsamut S, Eishingdrelo H Drug Discov Today. 2023; 28(8):103641.
PMID: 37236523 PMC: 10524340. DOI: 10.1016/j.drudis.2023.103641.
Zhou X, Shi M, Wang X, Xu D Front Chem. 2022; 10:921695.
PMID: 35646830 PMC: 9133541. DOI: 10.3389/fchem.2022.921695.
Rho-Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology.
Wu M, Funahashi Y, Takano T, Hossen E, Ahammad R, Tsuboi D Neurochem Res. 2022; 47(9):2757-2772.
PMID: 35624196 DOI: 10.1007/s11064-022-03623-y.