BRCA1/BARD1 is a Nucleosome Reader and Writer

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2022 Mar 30

PMID 35351360

Authors

Samuel R Witus

Weixing Zhao

Peter S Brzovic

Rachel E Klevit

Affiliations

Soon will be listed here.

Abstract

Mutations in BRCA1 and BARD1 predispose carriers to breast and ovarian cancers. The BRCA1 and BARD1 proteins form a heterodimeric complex (BRCA1/BARD1) that regulates many biological processes, including transcription and DNA double-stranded break repair. These functions are mediated by the only known enzymatic activity of BRCA1/BARD1 in its capacity as an E3 ubiquitin ligase and its role as a central hub for many large protein complexes. But the mechanisms by which BRCA1/BARD1 interfaces with chromatin, where it exerts its major functions, have remained unknown. Here, we review recent advancements in structural and cellular biology that have provided critical insights into how BRCA1/BARD1 serves as both a nucleosome reader and writer to facilitate transcriptional regulation and DNA repair by homologous recombination.

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