A Case Report of Severe Fusobacterium Nucleatum Sepsis Secondary to Nephrectomy

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2022 Mar 30

PMID 35351006

Authors

Chang Liu

Qiming Jia

Lifeng Wang

Dong Yang

Affiliations

Soon will be listed here.

Abstract

Background: Fusobacterium nucleatum (F. nucleatum) is a resident anaerobic bacterium, which in rare cases may invade blood from the head and neck or the digestive tract to cause bacteremia and induce venous thrombosis. F. nucleatum is closely related to abdominal tumors, but it has not been reported in relation to renal tumors. We report herein a possible case.

Case Presentation: This patient had kidney cancer with thrombosis in the right renal vein but had no sign of infection. After radical nephrectomy, thrombi formed in his left renal vein, and when removed, severe sepsis occurred. He did not respond to treatment with antibiotics and died, but the blood culture done confirmed that he had F. nucleatum bacteremia.

Conclusion: F. nucleatum may also be associated with kidney cancer, and could cause post-operative renal vein thrombosis, and sepsis or septic shock after thrombectomy.

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References

Zheng L, Giri B . Gastrointestinal Variant of Lemierre Syndrome: Fusobacterium nucleatum Bacteremia-Associated Hepatic Vein Thrombosis: a Case Report and Literature Review. Am J Ther. 2014; 23(3):e933-6. DOI: 10.1097/MJT.0000000000000084. View

Ahn J, Sinha R, Pei Z, Dominianni C, Wu J, Shi J . Human gut microbiome and risk for colorectal cancer. J Natl Cancer Inst. 2013; 105(24):1907-11. PMC: 3866154. DOI: 10.1093/jnci/djt300. View

Park Y, Choi J, Yong D, Lee K, Kim J . Clinical features and prognostic factors of anaerobic infections: a 7-year retrospective study. Korean J Intern Med. 2009; 24(1):13-8. PMC: 2687653. DOI: 10.3904/kjim.2009.24.1.13. View

Yusuf E, Wybo I, Pierard D . Case series of patients with Fusobacterium nucleatum bacteremia with emphasis on the presence of cancer. Anaerobe. 2016; 39:1-3. DOI: 10.1016/j.anaerobe.2016.02.001. View

Moore C, Addison D, Wilson J, Zeluff B . First case of Fusobacterium necrophorum endocarditis to have presented after the 2nd decade of life. Tex Heart Inst J. 2013; 40(4):449-52. PMC: 3783136. View

Nia A, Ungersboeck A, Uffmann M, Leaper D, Assadian O . Septic hip abscess due to Fusobacterium nucleatum and Actinomyces turicensis in an immunocompetent SARS-CoV-2 positive patient. Anaerobe. 2021; 71:102420. PMC: 8305297. DOI: 10.1016/j.anaerobe.2021.102420. View

Gavazzi G, Krause K . Ageing and infection. Lancet Infect Dis. 2002; 2(11):659-66. DOI: 10.1016/s1473-3099(02)00437-1. View

Pett E, Saeed K, Dryden M . Fusobacterium species infections: clinical spectrum and outcomes at a district general hospital. Infection. 2013; 42(2):363-70. DOI: 10.1007/s15010-013-0564-2. View

Le Roux K, Seve P, Gomard E, Boibieux A, Beziat C, Stankovic K . [Lemierre syndrome variant: Hepatic abscesses and hepatic venous thrombosis due to Fusobacterium nucleatum septicemia]. Rev Med Interne. 2006; 27(6):482-6. DOI: 10.1016/j.revmed.2005.12.013. View

10.

Forrester L, Campbell B, Berg J, Barrett J . Aggregation of platelets by Fusobacterium necrophorum. J Clin Microbiol. 1985; 22(2):245-9. PMC: 268368. DOI: 10.1128/jcm.22.2.245-249.1985. View

11.

Goldstein E . Anaerobic bacteremia. Clin Infect Dis. 1996; 23 Suppl 1:S97-101. DOI: 10.1093/clinids/23.supplement_1.s97. View

12.

Cao S, Hinchey S . Identification and Management of Fusobacterium Nucleatum Liver Abscess and Bacteremia in a Young Healthy Man. Cureus. 2021; 12(12):e12303. PMC: 7834589. DOI: 10.7759/cureus.12303. View

13.

Garcia-Carretero R . Bacteraemia and multiple liver abscesses due to in a patient with oropharyngeal malignancy. BMJ Case Rep. 2019; 12(1). PMC: 6352811. DOI: 10.1136/bcr-2018-228237. View

14.

Nohrstrom E, Mattila T, Pettila V, Kuusela P, Carlson P, Kentala E . Clinical spectrum of bacteraemic Fusobacterium infections: from septic shock to nosocomial bacteraemia. Scand J Infect Dis. 2011; 43(6-7):463-70. DOI: 10.3109/00365548.2011.565071. View

15.

Afra K, Laupland K, Leal J, Lloyd T, Gregson D . Incidence, risk factors, and outcomes of Fusobacterium species bacteremia. BMC Infect Dis. 2013; 13:264. PMC: 3679863. DOI: 10.1186/1471-2334-13-264. View

16.

Williams M, Kerber C, Tergin H . Unusual presentation of Lemierre's syndrome due to Fusobacterium nucleatum. J Clin Microbiol. 2003; 41(7):3445-8. PMC: 165296. DOI: 10.1128/JCM.41.7.3445-3448.2003. View

17.

Huggan P, Murdoch D . Fusobacterial infections: clinical spectrum and incidence of invasive disease. J Infect. 2008; 57(4):283-9. DOI: 10.1016/j.jinf.2008.07.016. View

18.

Mellor T, Mitchell N, Logan J . Lemierre's syndrome variant of the gut. BMJ Case Rep. 2017; 2017. PMC: 5665355. DOI: 10.1136/bcr-2017-221567. View

19.

Rahmati E, She R, Kazmierski B, Jan Geiseler P, Wong D . A case of liver abscess and fusobacterium septicemia. IDCases. 2017; 9:98-100. PMC: 5510492. DOI: 10.1016/j.idcr.2017.06.013. View

20.

Kostic A, Chun E, Robertson L, Glickman J, Gallini C, Michaud M . Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 2013; 14(2):207-15. PMC: 3772512. DOI: 10.1016/j.chom.2013.07.007. View