Aging, VO Max, Entropy, and COVID-19

Overview

Journal Indian J Pharmacol

Specialty Pharmacology

Date 2022 Mar 28

PMID 35343209

Authors

Michael Spedding

Robin Marvaud

Adrien Marck

Quentin Delarochelambert

Jean Francois Toussaint

Affiliations

Soon will be listed here.

Abstract

The decline in human performance with age at 5000 m, an athletic event requiring high VO max, is remarkably precise, and unavoidable, and related to entropy, even at an individual level. Women and men show an identical age-related decline, up to ~100 years old. The precision of the decline shows the limitations for therapy of aging. Mortality incidence for COVID-19 shows a similar relationship. We propose that initial VO max has a critical role in COVID sensitivity because of the direct relationship of disease severity with oxygen use, and the parallel decline in aging.

Citing Articles

Exploring the Hidden Complexity: Entropy Analysis in Pulse Oximetry of Female Athletes.

Cabanas A, Fuentes-Guajardo M, Saez N, Catalan D, Collao-Caiconte P, Martin-Escudero P Biosensors (Basel). 2024; 14(1).

PMID: 38275305 PMC: 11154467. DOI: 10.3390/bios14010052.

Drug Repurposing of Generic Drugs: Challenges and the Potential Role for Government.

van der Pol K, Aljofan M, Blin O, Cornel J, Rongen G, Woestelandt A Appl Health Econ Health Policy. 2023; 21(6):831-840.

PMID: 37398987 PMC: 10627937. DOI: 10.1007/s40258-023-00816-6.

COVID-19 and athletes: Endurance sport and activity resilience study-CAESAR study.

Sliz D, Wiecha S, Ulaszewska K, Gasior J, Lewandowski M, Kasiak P Front Physiol. 2023; 13:1078763.

PMID: 36589442 PMC: 9800893. DOI: 10.3389/fphys.2022.1078763.

References

De Larochelambert Q, Marc A, Antero J, Le Bourg E, Toussaint J . Covid-19 Mortality: A Matter of Vulnerability Among Nations Facing Limited Margins of Adaptation. Front Public Health. 2020; 8:604339. PMC: 7710830. DOI: 10.3389/fpubh.2020.604339. View

Spiegelhalter D . Use of "normal" risk to improve understanding of dangers of covid-19. BMJ. 2020; 370:m3259. DOI: 10.1136/bmj.m3259. View

Nielsen J, Gejl K, Hey-Mogensen M, Holmberg H, Suetta C, Krustrup P . Plasticity in mitochondrial cristae density allows metabolic capacity modulation in human skeletal muscle. J Physiol. 2016; 595(9):2839-2847. PMC: 5407961. DOI: 10.1113/JP273040. View

Chotiwan N, Andre B, Sanchez-Vargas I, Islam M, Grabowski J, Hopf-Jannasch A . Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes. PLoS Pathog. 2018; 14(2):e1006853. PMC: 5814098. DOI: 10.1371/journal.ppat.1006853. View

Kilding A, Winter E, Fysh M . A comparison of pulmonary oxygen uptake kinetics in middle- and long-distance runners. Int J Sports Med. 2006; 27(5):419-26. DOI: 10.1055/s-2005-865778. View

Berthelot G, Johnson S, Noirez P, Antero J, Marck A, Desgorces F . The age-performance relationship in the general population and strategies to delay age related decline in performance. Arch Public Health. 2019; 77:51. PMC: 6900856. DOI: 10.1186/s13690-019-0375-8. View

Marck A, Antero J, Berthelot G, Sauliere G, Jancovici J, Masson-Delmotte V . Are We Reaching the Limits of ?. Front Physiol. 2017; 8:812. PMC: 5662890. DOI: 10.3389/fphys.2017.00812. View

Aburto J, Scholey J, Kashnitsky I, Zhang L, Rahal C, Missov T . Quantifying impacts of the COVID-19 pandemic through life-expectancy losses: a population-level study of 29 countries. Int J Epidemiol. 2021; 51(1):63-74. PMC: 8500096. DOI: 10.1093/ije/dyab207. View

Rahman A, Tabassum T, Araf Y, Nahid A, Ullah M, Hosen M . Silent hypoxia in COVID-19: pathomechanism and possible management strategy. Mol Biol Rep. 2021; 48(4):3863-3869. PMC: 8062941. DOI: 10.1007/s11033-021-06358-1. View

10.

Hayflick L . Biological aging is no longer an unsolved problem. Ann N Y Acad Sci. 2007; 1100:1-13. DOI: 10.1196/annals.1395.001. View

11.

Golubev A . COVID-19: A Challenge to Physiology of Aging. Front Physiol. 2020; 11:584248. PMC: 7745705. DOI: 10.3389/fphys.2020.584248. View

12.

Li Q, Bozek K, Xu C, Guo Y, Sun J, Paabo S . Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys. Mol Biol Evol. 2017; 34(5):1155-1166. PMC: 5400384. DOI: 10.1093/molbev/msx065. View

13.

Rattray N, Trivedi D, Xu Y, Chandola T, Johnson C, Marshall A . Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty. Nat Commun. 2019; 10(1):5027. PMC: 6831565. DOI: 10.1038/s41467-019-12716-2. View

14.

Zhou L, Chen S, Han H, Sun J . Lactate augments intramuscular triglyceride accumulation and mitochondrial biogenesis in rats. J Biol Regul Homeost Agents. 2021; 35(1):105-115. DOI: 10.23812/20-624-A. View

15.

Marzetti E, Calvani R, Tosato M, Cesari M, Bari M, Cherubini A . Physical activity and exercise as countermeasures to physical frailty and sarcopenia. Aging Clin Exp Res. 2017; 29(1):35-42. DOI: 10.1007/s40520-016-0705-4. View

16.

Kirkwood T . Deciphering death: a commentary on Gompertz (1825) 'On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies'. Philos Trans R Soc Lond B Biol Sci. 2015; 370(1666). PMC: 4360127. DOI: 10.1098/rstb.2014.0379. View

17.

Garatachea N, Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Fiuza-Luces C, Moran M . Exercise attenuates the major hallmarks of aging. Rejuvenation Res. 2014; 18(1):57-89. PMC: 4340807. DOI: 10.1089/rej.2014.1623. View

18.

Kilding A, Winter E, Fysh M . Moderate-domain pulmonary oxygen uptake kinetics and endurance running performance. J Sports Sci. 2006; 24(9):1013-22. DOI: 10.1080/02640410500457208. View

19.

Shephard R . Maximal oxygen intake and independence in old age. Br J Sports Med. 2008; 43(5):342-6. DOI: 10.1136/bjsm.2007.044800. View

20.

Khrameeva E, Kurochkin I, Bozek K, Giavalisco P, Khaitovich P . Lipidome Evolution in Mammalian Tissues. Mol Biol Evol. 2018; 35(8):1947-1957. PMC: 6063302. DOI: 10.1093/molbev/msy097. View