» Articles » PMID: 35342458

Osteoporosis in 10 Years Time: a Glimpse into the Future of Osteoporosis

Overview
Date 2022 Mar 28
PMID 35342458
Authors
Affiliations
Soon will be listed here.
Abstract

Patients living with osteoporosis are projected to increase dramatically in the next decade. Alongside the forecasted increased societal and economic burden, we will live a crisis of fractures. However, we will have novel pharmacological treatment to face this crisis and, more importantly, new optimized treatment strategies. Fracture liaison services will be probably implemented on a large scale worldwide, helping to prevent additional fractures in high-risk patients. In the next decade, novel advances in the diagnostic tools will be largely available. Moreover, new and more precise fracture risk assessment tools will change our ability to detect patients at high risk of fractures. Finally, big data and artificial intelligence will help us to move forward into the world of precision medicine. In the present review, we will discuss the future epidemiology and costs of osteoporosis, the advances in early and accurate diagnosis of osteoporosis, with a special focus on biomarkers and imaging tools. Then we will examine new and refined fracture risk assessment tools, the role of fracture liaison services, and a future perspective on osteoporosis treatment.

Citing Articles

Proposed practice parameters for the performance of radiofrequency echographic multispectrometry (REMS) evaluations.

Zambito K, Kushchayeva Y, Bush A, Pisani P, Kushchayeva S, Peters M Bone Jt Open. 2025; 6(3):291-297.

PMID: 40049216 PMC: 11884906. DOI: 10.1302/2633-1462.63.BJO-2024-0107.R1.


Effect of vertebral kyphoplasty versus vertebroplasty on pain and indicators of imaging parameters of the injured vertebrae in patients with osteoporotic vertebral compression fractures: a meta-analysis.

You Z, Wu K, Jiang Y, Chen J J Orthop Surg Res. 2025; 20(1):199.

PMID: 40001072 PMC: 11863920. DOI: 10.1186/s13018-025-05621-6.


Association between air pollution and osteoporosis: A Mendelian randomization study.

Ju M, Liu F, Deng T, Jia X, Xu W, Zhang F Medicine (Baltimore). 2025; 104(8):e41490.

PMID: 39993078 PMC: 11856944. DOI: 10.1097/MD.0000000000041490.


Are Dietary Patterns Relevant for Reducing the Risk of Fractures and Sarcopenia?.

Welch A, Scott J, Cameron D, Yates M Curr Osteoporos Rep. 2025; 23(1):7.

PMID: 39847227 PMC: 11759455. DOI: 10.1007/s11914-024-00899-7.


Associations of Serum Homocysteine with Bone Mineral Density and Osteoporosis Incidence in Chinese Middle-Aged and Older Adults: A Retrospective Cohort Study.

Zou J, Shu M, Chen J, Wusiman M, Ye J, Yang S Nutrients. 2025; 17(1.

PMID: 39796626 PMC: 11723229. DOI: 10.3390/nu17010192.


References
1.
Samelson E, Broe K, Xu H, Yang L, Boyd S, Biver E . Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study. Lancet Diabetes Endocrinol. 2018; 7(1):34-43. PMC: 6354581. DOI: 10.1016/S2213-8587(18)30308-5. View

2.
Benny Lam S, Wald M, Rajapakse C, Liu Y, Saha P, Wehrli F . Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations. Bone. 2011; 49(4):895-903. PMC: 3167016. DOI: 10.1016/j.bone.2011.07.010. View

3.
Lamy O, Fernandez-Fernandez E, Monjo-Henry I, Stoll D, Aubry-Rozier B, Benavent-Nunez D . Alendronate after denosumab discontinuation in women previously exposed to bisphosphonates was not effective in preventing the risk of spontaneous multiple vertebral fractures: two case reports. Osteoporos Int. 2019; 30(5):1111-1115. DOI: 10.1007/s00198-018-04820-8. View

4.
Adami G, Saag K, Mudano A, Rahn E, Wright N, Outman R . Factors associated with the contemplative stage of readiness to initiate osteoporosis treatment. Osteoporos Int. 2020; 31(7):1283-1290. PMC: 7365553. DOI: 10.1007/s00198-020-05312-4. View

5.
Recker R, Benson C, Matsumoto T, Bolognese M, Robins D, Alam J . A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density. J Bone Miner Res. 2014; 30(2):216-24. DOI: 10.1002/jbmr.2351. View