Identifying Targets to Prevent Aminoglycoside Ototoxicity

Overview

Journal Mol Cell Neurosci

Specialties Cell Biology
Molecular Biology
Neurology

Date 2022 Mar 28

PMID 35341941

Authors

Jinkyung Kim

Sriram Hemachandran

Alan G Cheng

Anthony J Ricci

Affiliations

Soon will be listed here.

Abstract

Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we review recent advances in our understanding of aminoglycoside ototoxicity, mechanisms of drug transport, and promising sites for intervention to prevent ototoxicity.

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