Delivery of MRNA for Regulating Functions of Immune Cells

Overview

Journal J Control Release

Specialty Pharmacology

Date 2022 Mar 26

PMID 35337940

Authors

Jia Shi

Meng-Wen Huang

Zi-Dong Lu

Xiao-Jiao Du

Song Shen

Cong-Fei Xu

Jun Wang

Affiliations

Soon will be listed here.

Abstract

Abnormal immune cell functions are commonly related to various diseases, including cancer, autoimmune diseases, and infectious diseases. Messenger RNA (mRNA)-based therapy can regulate the functions of immune cells or assign new functions to immune cells, thereby generating therapeutic immune responses to treat these diseases. However, mRNA is unstable in physiological environments and can hardly enter the cytoplasm of target cells; thus, effective mRNA delivery systems are critical for developing mRNA therapy. The two mRNA vaccines of Pfizer-BioNTech and Moderna have demonstrated that lipid nanoparticles (LNPs) can deliver mRNA into dendritic cells (DCs) to induce immunization against severe acute respiratory syndrome coronavirus 2, which opened the floodgates to the development of mRNA therapy. Apart from DCs, other immune cells are promising targets for mRNA therapy. This review summarized the barriers to mRNA delivery and advances in mRNA delivery for regulating the functions of different immune cells.

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