α-Glucosidase and Bacterial β-Glucuronidase Inhibitors from the Stems of Staph

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2022 Mar 26

PMID 35337127

Authors

Guiwei Rao

Hangfei Yu

Manlai Zhang

Yuchen Cheng

Kun Ran

Jianwei Wang

Bin Wei

Min Li

Weiguang Shan

Zhajun Zhan

Youmin Ying

Affiliations

Soon will be listed here.

Abstract

α-Glucosidase (AGS) is a therapeutic target for Type 2 diabetes mellitus (T2DM) that tends to complicate with other diseases. Some medications for the treatment of T2DM complications have the risk of inducing severe adverse reactions such as diarrhea via the metabolism of intestinal bacterial β-glucuronidase (BGUS). The development of new AGS and/or BGUS inhibitors may improve the therapeutic effects of T2DM and its complications. The present work focused on the isolation and characterization of AGS and/or BGUS inhibitors from the medicinal plant . A total of eight compounds were isolated and identified. Sphaerandralide A () was obtained as a previously undescribed triterpenoid, which may have chemotaxonomy significance in the authentication of the genus and . 2'-acetyl-4',4-dimethoxybiphenyl-2-carbaldehyde () was obtained from a plant source for the first time, while compounds - were isolated from for the first time. In the in vitro assay, compounds - showed potent to moderate activity against AGS. Interestingly, compound also exhibited significant BGUS inhibitory activity, demonstrating the potential of being developed as a bifunctional inhibitor that may find application in the therapy of T2DM and/or the diarrhea induced by medications for the treatment of T2DM complications.

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