Jacaranone Derivatives with Antiproliferative Activity from and Relevance of This Group of Plant Metabolites

Overview

Journal Plants (Basel)

Date 2022 Mar 26

PMID 35336664

Authors

Csilla Zsuzsanna David

Norbert Kusz

Gyula Pinke

Agnes Kulmany

Istvan Zupko

Judit Hohmann

Andrea Vasas

Affiliations

Soon will be listed here.

Abstract

Jacaranones are a small group of specific plant metabolites with promising biological activities. The occurrence of jacaranones is limited to only a few plant families, with Asteraceae being the most abundant source of these compounds. Therefore, jacaranones can also serve as chemotaxonomic markers. Our phytochemical investigation of L. (Asteraceae) resulted in three jacaranone derivatives (jacaranone, 2,3-dihydro-2-hydroxyjacaranone, 2,3-dihydro-2-methoxyjacaranone), and (6,9)-3-oxo-α-ionol--d-glucopyranoside, fulgidic acid, 12,15-octadecadienoic acid methyl ester, scopoletin and apigenin-7---d-glucoside. This is the first report on the isolation of jacaranones from a species belonging to the Cichorioideae subfamily of Asteraceae. Jacaranone derivatives were subjected to an in vitro antiproliferative assay against a panel of human cancer cell lines (MCF-7, MDA-MB-231, HeLa, and C33A), revealing high or moderate activities, with IC values ranging from 6.3 to 26.5 μM.

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