Mediterranean Diet: A Tool to Break the Relationship of Atrial Fibrillation with the Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease

Overview

Journal Nutrients

Date 2022 Mar 26

PMID 35334916

Authors

Flavio Giuseppe Biccire

Tommaso Bucci

Danilo Menichelli

Vittoria Cammisotto

Pasquale Pignatelli

Roberto Carnevale

Daniele Pastori

Affiliations

Soon will be listed here.

Abstract

Atrial fibrillation (AF) is the most common supraventricular arrhythmia associated with increased cardiovascular and non-cardiovascular morbidity and mortality. As multiple factors may predispose the onset of AF, the prevention of the occurrence, recurrence and complications of this arrhythmia is still challenging. In particular, a high prevalence of cardio-metabolic comorbidities such as the metabolic syndrome (MetS) and in its hepatic manifestation, the non-alcoholic fatty liver disease (NAFLD), have been described in the AF population. A common pathogenetic mechanism linking AF, MetS and NAFLD is represented by oxidative stress. For this reason, in the past decades, numerous studies have investigated the effect of different foods/nutrients with antioxidant properties for the prevention of, and their therapeutic role is still unclear. In this narrative comprehensive review, we will summarize current evidence on (1) the association between AF, MetS and NAFLD (2) the antioxidant role of Mediterranean Diet and its components for the prevention of AF and (3) the effects of Mediterranean Diet on MetS components and NAFLD.

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References

Frost L, Vestergaard P . Alcohol and risk of atrial fibrillation or flutter: a cohort study. Arch Intern Med. 2004; 164(18):1993-8. DOI: 10.1001/archinte.164.18.1993. View

Umetani K, Kodama Y, Nakamura T, Mende A, Kitta Y, Kawabata K . High prevalence of paroxysmal atrial fibrillation and/or atrial flutter in metabolic syndrome. Circ J. 2007; 71(2):252-5. DOI: 10.1253/circj.71.252. View

Pastori D, Carnevale R, Pignatelli P . Is there a clinical role for oxidative stress biomarkers in atherosclerotic diseases?. Intern Emerg Med. 2013; 9(2):123-31. DOI: 10.1007/s11739-013-0999-6. View

Pastori D, Sciacqua A, Marcucci R, Ben M, Baratta F, Violi F . Non-alcoholic fatty liver disease (NAFLD), metabolic syndrome and cardiovascular events in atrial fibrillation. A prospective multicenter cohort study. Intern Emerg Med. 2021; 16(8):2063-2068. PMC: 8563662. DOI: 10.1007/s11739-021-02682-3. View

Bazal P, Gea A, Navarro A, Salas-Salvado J, Corella D, Alonso-Gomez A . Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts. Eur J Prev Cardiol. 2021; 28(6):648-657. DOI: 10.1177/2047487320909065. View

Larsson S, Drca N, Jensen-Urstad M, Wolk A . Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis. Am Heart J. 2017; 195:86-90. DOI: 10.1016/j.ahj.2017.09.013. View

Wuopio J, Orho-Melander M, Arnlov J, Nowak C . Estimated salt intake and risk of atrial fibrillation in a prospective community-based cohort. J Intern Med. 2020; 289(5):700-708. PMC: 8246952. DOI: 10.1111/joim.13194. View

Liu S, Manson J, Stampfer M, Holmes M, Hu F, Hankinson S . Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. Am J Clin Nutr. 2001; 73(3):560-6. DOI: 10.1093/ajcn/73.3.560. View

Pastori D, Menichelli D, Del Sole F, Pignatelli P, Violi F . Long-Term Risk of Major Adverse Cardiac Events in Atrial Fibrillation Patients on Direct Oral Anticoagulants. Mayo Clin Proc. 2020; 96(3):658-665. DOI: 10.1016/j.mayocp.2020.06.057. View

10.

Pastori D, Pignatelli P, Farcomeni A, Menichelli D, Nocella C, Carnevale R . Aging-Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation. J Am Heart Assoc. 2016; 5(9). PMC: 5079030. DOI: 10.1161/JAHA.116.003682. View

11.

Alonso A, Yin X, Roetker N, Magnani J, Kronmal R, Ellinor P . Blood lipids and the incidence of atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis and the Framingham Heart Study. J Am Heart Assoc. 2014; 3(5):e001211. PMC: 4323837. DOI: 10.1161/JAHA.114.001211. View

12.

Li Y, Pastori D, Guo Y, Wang Y, Lip G . Risk factors for new-onset atrial fibrillation: A focus on Asian populations. Int J Cardiol. 2018; 261:92-98. DOI: 10.1016/j.ijcard.2018.02.051. View

13.

Zhang S, Zhuang X, Lin X, Zhong X, Zhou H, Sun X . Low-Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study. J Am Heart Assoc. 2019; 8(9):e011955. PMC: 6512089. DOI: 10.1161/JAHA.119.011955. View

14.

Van Name M, Savoye M, Chick J, Galuppo B, Feldstein A, Pierpont B . A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. J Nutr. 2020; 150(9):2314-2321. PMC: 7467848. DOI: 10.1093/jn/nxaa183. View

15.

Pastori D, Pignatelli P, Saliola M, Carnevale R, Vicario T, Ben M . Inadequate anticoagulation by Vitamin K Antagonists is associated with Major Adverse Cardiovascular Events in patients with atrial fibrillation. Int J Cardiol. 2015; 201:513-6. DOI: 10.1016/j.ijcard.2015.08.054. View

16.

Pastori D, Pignatelli P, Angelico F, Farcomeni A, Ben M, Vicario T . Incidence of myocardial infarction and vascular death in elderly patients with atrial fibrillation taking anticoagulants: relation to atherosclerotic risk factors. Chest. 2014; 147(6):1644-1650. DOI: 10.1378/chest.14-2414. View

17.

Ionin V, Baranova E, Zaslavskaya E, Petrishcheva E, Morozov A, Shlyakhto E . Galectin-3, N-terminal Propeptides of Type I and III Procollagen in Patients with Atrial Fibrillation and Metabolic Syndrome. Int J Mol Sci. 2020; 21(16). PMC: 7461109. DOI: 10.3390/ijms21165689. View

18.

Schwingshackl L, Bogensberger B, Bencic A, Knuppel S, Boeing H, Hoffmann G . Effects of oils and solid fats on blood lipids: a systematic review and network meta-analysis. J Lipid Res. 2018; 59(9):1771-1782. PMC: 6121943. DOI: 10.1194/jlr.P085522. View

19.

Pignatelli P, Pastori D, Carnevale R, Farcomeni A, Cangemi R, Nocella C . Serum NOX2 and urinary isoprostanes predict vascular events in patients with atrial fibrillation. Thromb Haemost. 2014; 113(3):617-24. DOI: 10.1160/TH14-07-0571. View

20.

Pastori D, Carnevale R, Nocella C, Novo M, Santulli M, Cammisotto V . Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet. J Am Heart Assoc. 2017; 6(6). PMC: 5669181. DOI: 10.1161/JAHA.117.005784. View