Comparison of the Effects of Penbutolol and Propranolol on Glomerular Filtration Rate in Hypertensive Patients with Impaired Renal Function

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1986 Oct 1

PMID 3533129

Citations 2

Authors

J van der Meulen

E Reijn

G A Heidendal

P L Oe

A J Donker

Affiliations

Soon will be listed here.

Abstract

Penbutolol and propranolol were administered orally in a dosage of 40 mg once daily and 80 mg twice daily, respectively to 12 patients with hypertension and impaired renal function. Both drugs caused a significant decrease in mean arterial pressure and heart rate. Serum creatinine concentration increased significantly by 10% during therapy with propranolol without concomitant decrease in creatinine clearance. No such effect was seen with penbutolol. GFR measured with [125I]-iothalamate showed no significant changes with both drugs.

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