Risk of Dementia According to Surgery Type: A Nationwide Cohort Study

Overview

Journal J Pers Med

Date 2022 Mar 25

PMID 35330467

Authors

Young Suk Kwon

Sang-Hwa Lee

Chulho Kim

Hyunjae Yu

Jong-Hee Sohn

Jae Jun Lee

Dong-Kyu Kim

Affiliations

Soon will be listed here.

Abstract

The relationship between dementia and surgery remains unclear. Research to elucidate the relationship between them is scarce, and conducting epidemiological research is complicated. This study aimed to investigate the incidence and risk of dementia according to the surgery type. We performed a retrospective propensity score-matched cohort study using nationwide representative cohort sample data from the Korean National Health Insurance Service in South Korea between 2003 and 2004. Incidence rates for dementia were obtained by dividing the number of patients with dementia by person-years at risk. To identify the risk of dementia according to the type of surgery, we investigated the hazard ratio by each surgery type. The incidence rates of dementia in control, musculoskeletal, and two or more surgeries groups were 9.66, 13.47, and 13.36 cases per 1000 person-years, respectively. The risk of dementia in the musculoskeletal and two or more surgeries groups was 1.44-fold higher (95% confidence interval (95% CI), 1.22-1.70) and 1.42-fold higher (95% CI, 1.17-1.72) than that in the control group, respectively. Patients who underwent musculoskeletal surgery and two or more surgeries had a higher risk of dementia; however, there was no association with the type of anesthesia administered.

Citing Articles

The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in Older Adults: A Narrative Review.

Willoughby-Dudley K, Darwin M, Davalos D Curr Alzheimer Res. 2024; 21(1):3-23.

PMID: 38623985 DOI: 10.2174/0115672050288199240408035201.

Association between surgery and rate of incident dementia in older adults: A population-based retrospective cohort study.

Reich K, Gill S, Eckenhoff R, Berger M, Austin P, Rochon P J Am Geriatr Soc. 2024; 72(5):1348-1359.

PMID: 38165146 PMC: 11090718. DOI: 10.1111/jgs.18736.

HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.

Zhang C, Chen X, Liu R, Zhao G Neurochem Res. 2023; 49(3):706-717.

PMID: 38055149 DOI: 10.1007/s11064-023-04060-1.

Effect of Chronic Rhinosinusitis on the Risk of Development of Rheumatoid Arthritis.

Lee I, Yang H, Ha S, Son G, Kim D, Kim D Allergy Asthma Immunol Res. 2023; 15(5):647-658.

PMID: 37827981 PMC: 10570781. DOI: 10.4168/aair.2023.15.5.647.

Relationship of Depression, Anxiety, and Bipolar Disease with Burning Mouth Syndrome: A Nationwide Cohort Study.

Lee S, Kim C, Yu H, Kim D Int J Environ Res Public Health. 2023; 20(4).

PMID: 36834086 PMC: 9959042. DOI: 10.3390/ijerph20043391.

References

Bunch T, Weiss J, Crandall B, May H, Bair T, Osborn J . Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia. Heart Rhythm. 2010; 7(4):433-7. DOI: 10.1016/j.hrthm.2009.12.004. View

Xie Z, Dong Y, Maeda U, Moir R, Inouye S, Culley D . Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci. 2007; 61(12):1300-6. DOI: 10.1093/gerona/61.12.1300. View

Charlson M, Pompei P, Ales K, MacKenzie C . A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40(5):373-83. DOI: 10.1016/0021-9681(87)90171-8. View

Choi G, Kang H, Baek C, Jung Y, Kim J, Woo Y . Relationship between general anesthesia and Alzheimer disease: A protocol for a systematic review and meta-analysis. Medicine (Baltimore). 2018; 96(51):e9314. PMC: 5758206. DOI: 10.1097/MD.0000000000009314. View

Lu Y, Wu X, Dong Y, Xu Z, Zhang Y, Xie Z . Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice. Anesthesiology. 2010; 112(6):1404-16. PMC: 2877754. DOI: 10.1097/ALN.0b013e3181d94de1. View

Aarsland D, Sardahaee F, Anderssen S, Ballard C . Is physical activity a potential preventive factor for vascular dementia? A systematic review. Aging Ment Health. 2010; 14(4):386-95. DOI: 10.1080/13607860903586136. View

Seitz D, Shah P, Herrmann N, Beyene J, Siddiqui N . Exposure to general anesthesia and risk of Alzheimer's disease: a systematic review and meta-analysis. BMC Geriatr. 2011; 11:83. PMC: 3258207. DOI: 10.1186/1471-2318-11-83. View

Boyd A, Benjamin H, Asplund C . Splints and casts: indications and methods. Am Fam Physician. 2009; 80(5):491-9. View

Rusanen M, Kivipelto M, Quesenberry Jr C, Zhou J, Whitmer R . Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. Arch Intern Med. 2010; 171(4):333-9. DOI: 10.1001/archinternmed.2010.393. View

10.

Shavit Y, Weidenfeld J, DeKeyser F, Fish G, Wolf G, Mayburd E . Effects of surgical stress on brain prostaglandin E2 production and on the pituitary-adrenal axis: attenuation by preemptive analgesia and by central amygdala lesion. Brain Res. 2005; 1047(1):10-7. DOI: 10.1016/j.brainres.2005.04.003. View

11.

Lee D, Jo J, Jung J, Kim S . Prognostic Factors Predicting Early Recovery of Pre-fracture Functional Mobility in Elderly Patients With Hip Fracture. Ann Rehabil Med. 2015; 38(6):827-35. PMC: 4280380. DOI: 10.5535/arm.2014.38.6.827. View

12.

Sprung J, Jankowski C, Roberts R, Weingarten T, Aguilar A, Runkle K . Anesthesia and incident dementia: a population-based, nested, case-control study. Mayo Clin Proc. 2013; 88(6):552-61. PMC: 3784020. DOI: 10.1016/j.mayocp.2013.01.024. View

13.

Larsen S, Zaric D, Boysen G . Postoperative cerebrovascular accidents in general surgery. Acta Anaesthesiol Scand. 1988; 32(8):698-701. DOI: 10.1111/j.1399-6576.1988.tb02811.x. View

14.

Iwasaki M, Edmondson M, Sakamoto A, Ma D . Anesthesia, surgical stress, and "long-term" outcomes. Acta Anaesthesiol Taiwan. 2015; 53(3):99-104. DOI: 10.1016/j.aat.2015.07.002. View

15.

Chen P, Yang C, Tseng Y, Sun W, Wang J, Wang S . Risk of dementia after anaesthesia and surgery. Br J Psychiatry. 2013; 204(3):188-93. PMC: 3939441. DOI: 10.1192/bjp.bp.112.119610. View

16.

Cornella N, Sancho J, Sitges-Serra A . Short and Long-Term Outcomes After Surgical Procedures Lasting for More Than Six Hours. Sci Rep. 2017; 7(1):9221. PMC: 5569056. DOI: 10.1038/s41598-017-09833-7. View

17.

Tannenbaum C, Paquette A, Hilmer S, Holroyd-Leduc J, Carnahan R . A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs Aging. 2012; 29(8):639-58. DOI: 10.1007/BF03262280. View

18.

Kim C, Myung W, Lewis M, Lee H, Kim S, Lee K . Exposure to General Anesthesia and Risk of Dementia: A Nationwide Population-Based Cohort Study. J Alzheimers Dis. 2018; 63(1):395-405. DOI: 10.3233/JAD-170951. View

19.

Yang C, Fuh J . Exposure to general anesthesia and the risk of dementia. J Pain Res. 2015; 8:711-8. PMC: 4621175. DOI: 10.2147/JPR.S55579. View

20.

Xu W, Atti A, Gatz M, Pedersen N, Johansson B, Fratiglioni L . Midlife overweight and obesity increase late-life dementia risk: a population-based twin study. Neurology. 2011; 76(18):1568-74. PMC: 3100125. DOI: 10.1212/WNL.0b013e3182190d09. View