Analysis of Antidepressant, Benzodiazepine Anxiolytic, and Hypnotic Use When Treating Depression, Anxiety, and Aggression in Pain Clinic Patients Treated for Neuropathic Pain

Overview

Journal Life (Basel)

Specialty Biology

Date 2022 Mar 25

PMID 35330184

Authors

Marcin Kolacz

Dariusz Kosson

Ewa Puchalska-Kowalczyk

Malgorzata Mikaszewska-Sokolewicz

Barbara Lisowska

Malgorzata Malec-Milewska

Affiliations

Soon will be listed here.

Abstract

Depression, anxiety, and aggression accompany neuropathic pain. Effective treatment of these comorbidities enhances the outcomes of pain management. Therefore, the study was designed to analyze the relationship between the intensity of depression, anxiety, and aggression and the pharmacotherapy applied in the daily practice of treating neuropathic pain. The aim of the study was to evaluate the frequency of using antidepressants (ADs), benzodiazepine anxiolytics (BDAs), and hypnotics, and the influence of administering these on the intensity of depression, anxiety, and aggression in patients diagnosed with neuropathic pain. A multi-center survey was conducted among 421 patients. An evaluation of the severity of depression, anxiety, and aggression was made using the Hospital Anxiety and Depression Scale-Modified Version (HADS-M). Among the patients treated due to neuropathic pain, ADs are used much more often than BDAs and hypnotics. Depression was well controlled, while anxiety was identified as a possible uncontrolled therapeutic problem in these patients, despite the correlation between the frequency of AD and hypnotics usage and the severity of anxiety. We also found that women show a higher level of intensity in both anxiety and depression, but this does not influence the frequency of their being administered ADs, BDAs, and hypnotics.

Citing Articles

Naphthoquinone fused diazepines targeting hyperamylasemia: potential therapeutic agents for diabetes and cancer.

Chahal S, Rani P, Singh R, Joshi G, Kumar R, Kumar P Future Med Chem. 2024; 16(21):2231-2245.

PMID: 39301934 PMC: 11622778. DOI: 10.1080/17568919.2024.2400968.

Analysis of Influencing Factors of Major Depression After Spinal Cord Injury.

Tang Z, Yu X Alpha Psychiatry. 2024; 25(3):395-400.

PMID: 39148589 PMC: 11322723. DOI: 10.5152/alphapsychiatry.2024.241526.

Central nervous system active medication use in Medicare enrollees receiving home health care: association with chronic pain and anxiety level.

Raji M, Shah R, Westra J, Kuo Y Pain. 2024; 166(1):123-129.

PMID: 38985202 PMC: 11649488. DOI: 10.1097/j.pain.0000000000003331.

Patterns and Trends in Pharmacological Treatment for Outpatients with Postherpetic Neuralgia in Six Major Areas of China, 2015-2019.

Han G, Han Y, Yu L, Zhao Y, Yu Z Healthcare (Basel). 2023; 11(5).

PMID: 36900769 PMC: 10000853. DOI: 10.3390/healthcare11050764.

Correlations of kratom (Mitragyna speciosa Korth.) use behavior and psychiatric conditions from a cross-sectional survey.

Grundmann O, Veltri C, Morcos S, Smith K, Singh D, Corazza O Exp Clin Psychopharmacol. 2023; 31(5):963-977.

PMID: 36634016 PMC: 10336173. DOI: 10.1037/pha0000632.

References

Humo M, Lu H, Yalcin I . The molecular neurobiology of chronic pain-induced depression. Cell Tissue Res. 2019; 377(1):21-43. DOI: 10.1007/s00441-019-03003-z. View

Wohlreich M, Sullivan M, Mallinckrodt C, Chappell A, Oakes T, Watkin J . Duloxetine for the treatment of recurrent major depressive disorder in elderly patients: treatment outcomes in patients with comorbid arthritis. Psychosomatics. 2009; 50(4):402-12. DOI: 10.1176/appi.psy.50.4.402. View

Khosravi H, Khalilzadeh E, Vafaei Saiah G . Pain-induced aggression and changes in social behavior in mice. Aggress Behav. 2020; 47(1):89-98. DOI: 10.1002/ab.21912. View

Smith G . The epidemiology and treatment of depression when it coexists with somatoform disorders, somatization, or pain. Gen Hosp Psychiatry. 1992; 14(4):265-72. DOI: 10.1016/0163-8343(92)90097-t. View

Nicholson B, Verma S . Comorbidities in chronic neuropathic pain. Pain Med. 2004; 5 Suppl 1:S9-S27. DOI: 10.1111/j.1526-4637.2004.04019.x. View

Sundbom L, Bingefors K, Hedborg K, Isacson D . Are men under-treated and women over-treated with antidepressants? Findings from a cross-sectional survey in Sweden. BJPsych Bull. 2017; 41(3):145-150. PMC: 5451647. DOI: 10.1192/pb.bp.116.054270. View

Gauntlett-Gilbert J, Gavriloff D, Brook P . Benzodiazepines May be Worse Than Opioids: Negative Medication Effects in Severe Chronic Pain. Clin J Pain. 2015; 32(4):285-91. DOI: 10.1097/AJP.0000000000000253. View

Williams L, Jones W, Shen J, Robinson R, Weinberger M, Kroenke K . Prevalence and impact of depression and pain in neurology outpatients. J Neurol Neurosurg Psychiatry. 2003; 74(11):1587-9. PMC: 1738243. DOI: 10.1136/jnnp.74.11.1587. View

Lu Y, Li J, Liu Y . Depression as a mediator of quality of life in patients with neuropathic pain: A cross-sectional study. J Adv Nurs. 2019; 75(11):2719-2726. DOI: 10.1111/jan.14111. View

10.

Keers R, Aitchison K . Gender differences in antidepressant drug response. Int Rev Psychiatry. 2010; 22(5):485-500. DOI: 10.3109/09540261.2010.496448. View

11.

Sheng J, Liu S, Wang Y, Cui R, Zhang X . The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain. Neural Plast. 2017; 2017:9724371. PMC: 5494581. DOI: 10.1155/2017/9724371. View

12.

Cherif F, Zouari H, Cherif W, Hadded M, Cheour M, Damak R . Depression Prevalence in Neuropathic Pain and Its Impact on the Quality of Life. Pain Res Manag. 2020; 2020:7408508. PMC: 7315316. DOI: 10.1155/2020/7408508. View

13.

Koen N, Stein D . Pharmacotherapy of anxiety disorders: a critical review. Dialogues Clin Neurosci. 2012; 13(4):423-37. PMC: 3263390. View

14.

Bomalaski M, Claflin E, Townsend W, Peterson M . Zolpidem for the Treatment of Neurologic Disorders: A Systematic Review. JAMA Neurol. 2017; 74(9):1130-1139. DOI: 10.1001/jamaneurol.2017.1133. View

15.

Goedhard L, Stolker J, Heerdink E, Nijman H, Olivier B, Egberts T . Pharmacotherapy for the treatment of aggressive behavior in general adult psychiatry: A systematic review. J Clin Psychiatry. 2006; 67(7):1013-24. DOI: 10.4088/jcp.v67n0702. View

16.

Weissman M, Klerman G . Sex differences and the epidemiology of depression. Arch Gen Psychiatry. 1977; 34(1):98-111. DOI: 10.1001/archpsyc.1977.01770130100011. View

17.

Haanpaa M, Attal N, Backonja M, Baron R, Bennett M, Bouhassira D . NeuPSIG guidelines on neuropathic pain assessment. Pain. 2010; 152(1):14-27. DOI: 10.1016/j.pain.2010.07.031. View

18.

Boadas-Vaello P, Homs J, Reina F, Carrera A, Verdu E . Neuroplasticity of Supraspinal Structures Associated with Pathological Pain. Anat Rec (Hoboken). 2017; 300(8):1481-1501. DOI: 10.1002/ar.23587. View

19.

Moore R, Derry S, Aldington D, Cole P, Wiffen P . Amitriptyline for neuropathic pain in adults. Cochrane Database Syst Rev. 2015; (7):CD008242. PMC: 6447238. DOI: 10.1002/14651858.CD008242.pub3. View

20.

Melek L, Smith J, Karamat A, Renton T . Comparison of the Neuropathic Pain Symptoms and Psychosocial Impacts of Trigeminal Neuralgia and Painful Posttraumatic Trigeminal Neuropathy. J Oral Facial Pain Headache. 2019; 33(1):77-88. DOI: 10.11607/ofph.2157. View