The Maternal-Fetal Gut Microbiota Axis: Physiological Changes, Dietary Influence, and Modulation Possibilities

Overview

Journal Life (Basel)

Specialty Biology

Date 2022 Mar 25

PMID 35330175

Authors

Eva Miko

Andras Csaszar

Jozsef Bodis

Kalman Kovacs

Affiliations

Soon will be listed here.

Abstract

The prenatal period and the first years of life have a significant impact on the health issues and life quality of an individual. The appropriate development of the immune system and the central nervous system are thought to be major critical determining events. In parallel to these, establishing an early intestinal microbiota community is another important factor for future well-being interfering with prenatal and postnatal developmental processes. This review aims at summarizing the main characteristics of maternal gut microbiota and its possible transmission to the offspring, thereby affecting fetal and/or neonatal development and health. Since maternal dietary factors are potential modulators of the maternal-fetal microbiota axis, we will outline current knowledge on the impact of certain diets, nutritional factors, and nutritional modulators during pregnancy on offspring's microbiota and health.

Citing Articles

The Microbiome-Genetics Axis in Autism Spectrum Disorders: A Probiotic Perspective.

Mihailovich M, Tolinacki M, Sokovic Bajic S, Lestarevic S, Pejovic-Milovancevic M, Golic N Int J Mol Sci. 2024; 25(22).

PMID: 39596472 PMC: 11594817. DOI: 10.3390/ijms252212407.

Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children.

Meng L, Yang Y, He S, Chen H, Zhan Y, Yang R BMC Med. 2024; 22(1):383.

PMID: 39267041 PMC: 11395239. DOI: 10.1186/s12916-024-03611-9.

Microbial Extracellular Vesicles in Host-Microbiota Interactions.

Abubaker S, Miri S, Mottawea W, Hammami R Results Probl Cell Differ. 2024; 73:475-520.

PMID: 39242390 DOI: 10.1007/978-3-031-62036-2_19.

Effects of dietary restriction and one-carbon metabolite supplementation during the first 63 days of gestation on the maternal gut, vaginal, and blood microbiota in cattle.

Luecke S, Aryee G, Holman D, Schmidt K, King L, Crouse M Anim Microbiome. 2024; 6(1):48.

PMID: 39210404 PMC: 11360793. DOI: 10.1186/s42523-024-00335-2.

Use of Cosmetics in Pregnancy and Neurotoxicity: Can It Increase the Risk of Congenital Enteric Neuropathies?.

Jones K, Wessel L, Schafer K, Tapia-Laliena M Biomolecules. 2024; 14(8).

PMID: 39199372 PMC: 11352589. DOI: 10.3390/biom14080984.

References

Laforest-Lapointe I, Becker A, Mandhane P, Turvey S, Moraes T, Sears M . Maternal consumption of artificially sweetened beverages during pregnancy is associated with infant gut microbiota and metabolic modifications and increased infant body mass index. Gut Microbes. 2020; 13(1):1-15. PMC: 7781635. DOI: 10.1080/19490976.2020.1857513. View

Dubinkina V, Tyakht A, Odintsova V, Yarygin K, Kovarsky B, Pavlenko A . Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease. Microbiome. 2017; 5(1):141. PMC: 5645934. DOI: 10.1186/s40168-017-0359-2. View

Kennedy K, Bellissimo C, Breznik J, Barrett J, Braun T, Bushman F . Over-celling fetal microbial exposure. Cell. 2021; 184(24):5839-5841. DOI: 10.1016/j.cell.2021.10.026. View

Bertelsen R, Brantsaeter A, Magnus M, Haugen M, Myhre R, Jacobsson B . Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases. J Allergy Clin Immunol. 2013; 133(1):165-71.e1-8. PMC: 3912862. DOI: 10.1016/j.jaci.2013.07.032. View

Kashtanova D, Popenko A, Tkacheva O, Tyakht A, Alexeev D, Boytsov S . Association between the gut microbiota and diet: Fetal life, early childhood, and further life. Nutrition. 2016; 32(6):620-7. DOI: 10.1016/j.nut.2015.12.037. View

Desbuards N, Gourbeyre P, Haure-Mirande V, Darmaun D, Champ M, Bodinier M . Impact of perinatal prebiotic consumption on gestating mice and their offspring: a preliminary report. Br J Nutr. 2011; 107(9):1245-8. DOI: 10.1017/S0007114511004363. View

Strunk T, Currie A, Richmond P, Simmer K, Burgner D . Innate immunity in human newborn infants: prematurity means more than immaturity. J Matern Fetal Neonatal Med. 2010; 24(1):25-31. DOI: 10.3109/14767058.2010.482605. View

Soderborg T, Carpenter C, Janssen R, Weir T, Robertson C, Ir D . Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota. Front Endocrinol (Lausanne). 2020; 11:603021. PMC: 7729132. DOI: 10.3389/fendo.2020.603021. View

Thum C, Cookson A, Otter D, McNabb W, Hodgkinson A, Dyer J . Can nutritional modulation of maternal intestinal microbiota influence the development of the infant gastrointestinal tract?. J Nutr. 2012; 142(11):1921-8. DOI: 10.3945/jn.112.166231. View

10.

Dominguez-Bello M, Godoy-Vitorino F, Knight R, Blaser M . Role of the microbiome in human development. Gut. 2019; 68(6):1108-1114. PMC: 6580755. DOI: 10.1136/gutjnl-2018-317503. View

11.

Collado M, Isolauri E, Laitinen K, Salminen S . Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr. 2008; 88(4):894-9. DOI: 10.1093/ajcn/88.4.894. View

12.

Collado M, Isolauri E, Laitinen K, Salminen S . Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy. Am J Clin Nutr. 2010; 92(5):1023-30. DOI: 10.3945/ajcn.2010.29877. View

13.

Daniel H . Diet and Gut Microbiome and the "Chicken or Egg" Problem. Front Nutr. 2022; 8:828630. PMC: 8844458. DOI: 10.3389/fnut.2021.828630. View

14.

Kobyliak N, Virchenko O, Falalyeyeva T . Pathophysiological role of host microbiota in the development of obesity. Nutr J. 2016; 15:43. PMC: 4841968. DOI: 10.1186/s12937-016-0166-9. View

15.

Fleming T, Watkins A, Velazquez M, Mathers J, Prentice A, Stephenson J . Origins of lifetime health around the time of conception: causes and consequences. Lancet. 2018; 391(10132):1842-1852. PMC: 5975952. DOI: 10.1016/S0140-6736(18)30312-X. View

16.

Walters W, Xu Z, Knight R . Meta-analyses of human gut microbes associated with obesity and IBD. FEBS Lett. 2014; 588(22):4223-33. PMC: 5050012. DOI: 10.1016/j.febslet.2014.09.039. View

17.

Wang J, Zheng J, Shi W, Du N, Xu X, Zhang Y . Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus. Gut. 2018; 67(9):1614-1625. PMC: 6109274. DOI: 10.1136/gutjnl-2018-315988. View

18.

Macpherson A, Uhr T . Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science. 2004; 303(5664):1662-5. DOI: 10.1126/science.1091334. View

19.

Peelen M, Moller Luef B, Lamont R, De Milliano I, Jensen J, Limpens J . The influence of the vaginal microbiota on preterm birth: A systematic review and recommendations for a minimum dataset for future research. Placenta. 2019; 79:30-39. DOI: 10.1016/j.placenta.2019.03.011. View

20.

Mesa M, Loureiro B, Iglesia I, Fernandez Gonzalez S, Olive E, Garcia Algar O . The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review. Nutrients. 2020; 12(1). PMC: 7019214. DOI: 10.3390/nu12010133. View