Progress in the Development of Graphene-Based Biomaterials for Tissue Engineering and Regeneration

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2022 Mar 25

PMID 35329615

Authors

Chao Chen

Yuewei Xi

Yunxuan Weng

Affiliations

Soon will be listed here.

Abstract

Over the last few decades, tissue engineering has become an important technology for repairing and rebuilding damaged tissues and organs. The scaffold plays an important role and has become a hot pot in the field of tissue engineering. It has sufficient mechanical and biochemical properties and simulates the structure and function of natural tissue to promote the growth of cells inward. Therefore, graphene-based nanomaterials (GBNs), such as graphene and graphene oxide (GO), have attracted wide attention in the field of biomedical tissue engineering because of their unique structure, large specific surface area, good photo-thermal effect, pH response and broad-spectrum antibacterial properties. In this review, the structure and properties of typical GBNs are summarized, the progress made in the development of GBNs in soft tissue engineering (including skin, muscle, nerve and blood vessel) are highlighted, the challenges and prospects of the application of GBNs in soft tissue engineering have prospected.

Citing Articles

Graphene and its hybrid nanocomposite: A Metamorphoses elevation in the field of tissue engineering.

Singh R, Rawat H, Kumar A, Gandhi Y, Kumar V, Mishra S Heliyon. 2024; 10(13):e33542.

PMID: 39040352 PMC: 11261797. DOI: 10.1016/j.heliyon.2024.e33542.

Peripheral nerve injury repair by electrical stimulation combined with graphene-based scaffolds.

Zhao Y, Liu Y, Kang S, Sun D, Liu Y, Wang X Front Bioeng Biotechnol. 2024; 12:1345163.

PMID: 38481574 PMC: 10933080. DOI: 10.3389/fbioe.2024.1345163.

Effects of mechanical properties of carbon-based nanocomposites on scaffolds for tissue engineering applications: a comprehensive review.

Eivazzadeh-Keihan R, Sadat Z, Lalebeigi F, Naderi N, Panahi L, Ganjali F Nanoscale Adv. 2024; 6(2):337-366.

PMID: 38235087 PMC: 10790973. DOI: 10.1039/d3na00554b.

Review of Piezoelectrical Materials Potentially Useful for Peripheral Nerve Repair.

Casal D, Casimiro M, Ferreira L, Leal J, Rodrigues G, Lopes R Biomedicines. 2023; 11(12).

PMID: 38137416 PMC: 10740581. DOI: 10.3390/biomedicines11123195.

Engineered Highly Porous Polyvinyl Alcohol Hydrogels with Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Graphene Nanosheets for Musculoskeletal Tissue Engineering: Morphology, Water Sorption, Thermal, Mechanical, Electrical Properties, and....

Aparicio-Collado J, Zheng Q, Molina-Mateo J, Torregrosa Cabanilles C, Vidaurre A, Serrano-Aroca A Materials (Basel). 2023; 16(8).

PMID: 37109950 PMC: 10145967. DOI: 10.3390/ma16083114.

References

Panwar N, Soehartono A, Chan K, Zeng S, Xu G, Qu J . Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery. Chem Rev. 2019; 119(16):9559-9656. DOI: 10.1021/acs.chemrev.9b00099. View

Jian Z, Wang H, Liu M, Chen S, Wang Z, Qian W . Polyurethane-modified graphene oxide composite bilayer wound dressing with long-lasting antibacterial effect. Mater Sci Eng C Mater Biol Appl. 2020; 111:110833. DOI: 10.1016/j.msec.2020.110833. View

Novoselov K, Geim A, Morozov S, Jiang D, Zhang Y, Dubonos S . Electric field effect in atomically thin carbon films. Science. 2004; 306(5696):666-9. DOI: 10.1126/science.1102896. View

Tzahor E, Poss K . Cardiac regeneration strategies: Staying young at heart. Science. 2017; 356(6342):1035-1039. PMC: 5614484. DOI: 10.1126/science.aam5894. View

Reith W . [Neurodegenerative diseases]. Radiologe. 2018; 58(3):241-258. DOI: 10.1007/s00117-018-0363-y. View

Corr S, Raoof M, Cisneros B, Kuznetsov O, Massey K, Kaluarachchi W . Cytotoxicity and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cells. Nanoscale Res Lett. 2013; 8(1):208. PMC: 3663679. DOI: 10.1186/1556-276X-8-208. View

Siew Q, Tham S, Loh H, Khiew P, Chiu W, Tan M . One-step green hydrothermal synthesis of biocompatible graphene/TiO nanocomposites for non-enzymatic HO detection and their cytotoxicity effects on human keratinocyte and lung fibroblast cells. J Mater Chem B. 2020; 6(8):1195-1206. DOI: 10.1039/c7tb02891a. View

Feng Z, Yan K, Shi C, Xu X, Wang T, Li R . Neurogenic differentiation of adipose derived stem cells on graphene-based mat. Mater Sci Eng C Mater Biol Appl. 2018; 90:685-692. DOI: 10.1016/j.msec.2018.05.019. View

Jones K, Patel N, Levy M, Storeygard A, Balk D, Gittleman J . Global trends in emerging infectious diseases. Nature. 2008; 451(7181):990-3. PMC: 5960580. DOI: 10.1038/nature06536. View

10.

Garg K, Corona B, Walters T . Therapeutic strategies for preventing skeletal muscle fibrosis after injury. Front Pharmacol. 2015; 6:87. PMC: 4404830. DOI: 10.3389/fphar.2015.00087. View

11.

Chen J, Alexander G, Bobba P, Jun H . Recent Progress in Vascular Tissue-Engineered Blood Vessels. Adv Exp Med Biol. 2018; 1064:123-144. DOI: 10.1007/978-981-13-0445-3_8. View

12.

Shin S, Zihlmann C, Akbari M, Assawes P, Cheung L, Zhang K . Reduced Graphene Oxide-GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineering. Small. 2016; 12(27):3677-89. PMC: 5201005. DOI: 10.1002/smll.201600178. View

13.

Cao G, Yan J, Ning X, Zhang Q, Wu Q, Bi L . Antibacterial and antibiofilm properties of graphene and its derivatives. Colloids Surf B Biointerfaces. 2021; 200:111588. DOI: 10.1016/j.colsurfb.2021.111588. View

14.

Naseri-Nosar M, Ziora Z . Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites. Carbohydr Polym. 2018; 189:379-398. DOI: 10.1016/j.carbpol.2018.02.003. View

15.

Dimitrievska S, Niklason L . Historical Perspective and Future Direction of Blood Vessel Developments. Cold Spring Harb Perspect Med. 2017; 8(2). PMC: 5685928. DOI: 10.1101/cshperspect.a025742. View

16.

Mohammadrezaei D, Golzar H, Rezai Rad M, Omidi M, Rashedi H, Yazdian F . In vitro effect of graphene structures as an osteoinductive factor in bone tissue engineering: A systematic review. J Biomed Mater Res A. 2018; 106(8):2284-2343. DOI: 10.1002/jbm.a.36422. View

17.

Shin Y, Lee J, Kim M, Hong S, Kim B, Hyun J . Stimulating effect of graphene oxide on myogenesis of C2C12 myoblasts on RGD peptide-decorated PLGA nanofiber matrices. J Biol Eng. 2015; 9:22. PMC: 4659147. DOI: 10.1186/s13036-015-0020-1. View

18.

Wychowaniec J, Litowczenko J, Tadyszak K, Natu V, Aparicio C, Peplinska B . Unique cellular network formation guided by heterostructures based on reduced graphene oxide - TiCT MXene hydrogels. Acta Biomater. 2020; 115:104-115. DOI: 10.1016/j.actbio.2020.08.010. View

19.

Qian Y, Song J, Zhao X, Chen W, Ouyang Y, Yuan W . 3D Fabrication with Integration Molding of a Graphene Oxide/Polycaprolactone Nanoscaffold for Neurite Regeneration and Angiogenesis. Adv Sci (Weinh). 2018; 5(4):1700499. PMC: 5908351. DOI: 10.1002/advs.201700499. View

20.

Yu R, Zhang H, Guo B . Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering. Nanomicro Lett. 2021; 14(1):1. PMC: 8639891. DOI: 10.1007/s40820-021-00751-y. View