MicroRNA-21 Expression As a Prognostic Biomarker in Oral Cancer: Systematic Review and Meta-Analysis

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Mar 25

PMID 35329083

Authors

Mario Dioguardi

Francesca Spirito

Diego Sovereto

Mario Alovisi

Giuseppe Troiano

Riccardo Aiuto

Daniele Garcovich

Vito Crincoli

Luigi Laino

Angela Pia Cazzolla

Giorgia Apollonia Caloro

Michele Di Cosola

Lorenzo Lo Muzio

Affiliations

Soon will be listed here.

Abstract

Methods: The systematic review was conducted following the PRISMA guidelines using electronic databases, such as PubMed, Scopus, and the Cochrane Central Register of Controlled Trials, with the use of combinations of keywords, such as miR-21 AND oral cancer, microRNA AND oral cancer, and miR-21. The meta-analysis was performed using the RevMan 5.41 software.

Results: At the end of the article-selection process, 10 studies were included in the meta-analysis, and the result for the main outcome was a pooled HR per overall survival (OS) of 1.29 (1.16-1.44) between high and low expression of miR-21.

Conclusions: The data in the literature and the results emerging from the systematic review indicate that miR-21 can provide a prognostic indication in oral cancer.

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