Baseline Complete Blood Count and Chemistry Panel Profile from the Japan Environment and Children's Study (JECS)

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Mar 25

PMID 35328967

Authors

Yu Taniguchi

Shin Yamazaki

Shoji F Nakayama

Makiko Sekiyama

Takehiro Michikawa

Tomohiko Isobe

Miyuki Iwai-Shimada

Yayoi Kobayashi

Mai Takagi

Michihiro Kamijima

The Japan Environment And Childrens Study Group

Affiliations

Soon will be listed here.

Abstract

Background: The Japan Environment and Children's Study (JECS) is a nationwide birth cohort study of environmental factors affecting children's health and development. We summarize the complete blood count and chemistry panel statistical data from pregnant women enrolled in JECS.

Methods: Statistical data of up to 58,056 mother's sample in their first (gestational age ≤ 13 weeks) and second trimester (22-27 weeks) were calculated.

Results: Mean (SD) values in the first trimester were: white blood cell count, 7866 (1906)/μL; red blood cell count, 417 (33) 10/μL; hemoglobin, 12.4 (1.0) g/dL; hematocrit, 37.1 (2.6)%; mean corpuscular volume, 89.2 (4.7) fL; mean corpuscular hemoglobin, 29.8 (1.9) pg; mean corpuscular hemoglobin concentration, 33.3 (0.9)%; platelet count, 24.8 (5.2) 10/μL; HbA1c, 5.26 (0.26)%; total cholesterol, 181 (28) mg/dL; low density lipoprotein cholesterol, 95 (23) mg/dL; high density lipoprotein cholesterol, 73 (13) mg/dL; free cholesterol, 41 (7) mg/dL; triglycerides, 109 (47) mg/dL; total protein, 6.9 (0.4) g/dL; and albumin, 4.1 (0.2) g/dL. Mean values (SD) in the second trimester were: total cholesterol, 246 (38) mg/dL; free cholesterol, 61 (9) mg/dL; triglycerides, 183 (70) mg/dL; total protein, 6.5 (0.4) g/dL; and albumin, 3.6 (0.2) g/dL.

Conclusions: These data will be useful for future JECS studies.

Citing Articles

Association between maternal cholesterol level during pregnancy and placental weight and birthweight ratio: data from the Japan Environment and Children's Study.

Mitsuda N, Eitoku M, Yamasaki K, J-P N, Fujieda M, Maeda N BMC Pregnancy Childbirth. 2023; 23(1):484.

PMID: 37391691 PMC: 10311780. DOI: 10.1186/s12884-023-05810-3.

References

Bartels A, ODonoghue K . Cholesterol in pregnancy: a review of knowns and unknowns. Obstet Med. 2016; 4(4):147-51. PMC: 4989641. DOI: 10.1258/om.2011.110003. View

Nakayama S, Iwai-Shimada M, Oguri T, Isobe T, Takeuchi A, Kobayashi Y . Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children's Study (JECS). J Expo Sci Environ Epidemiol. 2019; 29(5):633-647. PMC: 6760604. DOI: 10.1038/s41370-019-0139-0. View

Mitsuda N, J-P N, Eitoku M, Maeda N, Fujieda M, Suganuma N . Association between maternal hemoglobin concentration and placental weight to birthweight ratio: The Japan Environment and Children's Study (JECS). Placenta. 2020; 101:132-138. DOI: 10.1016/j.placenta.2020.09.014. View

Maher J, Goldenberg R, Tamura T, Cliver S, Hoffman H, Davis R . Albumin levels in pregnancy: a hypothesis--decreased levels of albumin are related to increased levels of alpha-fetoprotein. Early Hum Dev. 1993; 34(3):209-15. DOI: 10.1016/0378-3782(93)90178-w. View

Jung C, Nishihama Y, Nakayama S, Tamura K, Isobe T, Michikawa T . Indoor air quality of 5,000 households and its determinants. Part B: Volatile organic compounds and inorganic gaseous pollutants in the Japan Environment and Children's study. Environ Res. 2021; 197:111135. DOI: 10.1016/j.envres.2021.111135. View

Sasaki H, Arata N, Tomotaki A, Yamamoto-Hanada K, Mezawa H, Konishi M . Time course of metabolic status in pregnant women: The Japan Environment and Children's Study. J Diabetes Investig. 2020; 11(5):1318-1325. PMC: 7477532. DOI: 10.1111/jdi.13238. View

Ishitsuka K, Sasaki S, Yamamoto-Hanada K, Mezawa H, Konishi M, Ohya Y . Changes in Dietary Intake in Pregnant Women from Periconception to Pregnancy in the Japan Environment and Children's Study: A Nationwide Japanese Birth Cohort Study. Matern Child Health J. 2020; 24(3):389-400. DOI: 10.1007/s10995-019-02835-z. View

Iwai-Shimada M, Nakayama S, Isobe T, Michikawa T, Yamazaki S, Nitta H . Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children Study (JECS). Environ Health Prev Med. 2018; 23(1):45. PMC: 6138908. DOI: 10.1186/s12199-018-0733-0. View

Kaneko K, Ito Y, Ebara T, Kato S, Matsuki T, Tamada H . Association of Maternal Total Cholesterol With SGA or LGA Birth at Term: the Japan Environment and Children's Study. J Clin Endocrinol Metab. 2021; 107(1):e118-e129. PMC: 8684489. DOI: 10.1210/clinem/dgab618. View

10.

Nishihama Y, Jung C, Nakayama S, Tamura K, Isobe T, Michikawa T . Indoor air quality of 5,000 households and its determinants. Part A: Particulate matter (PM and PM) concentrations in the Japan Environment and Children's Study. Environ Res. 2021; 198:111196. DOI: 10.1016/j.envres.2021.111196. View

11.

Yang L, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Mezawa H, Konishi M . Medical and surgical complications in pregnancy and obstetric labour complications in the Japan Environment and Children's Study (JECS) cohort: a birth cohort study. J Obstet Gynaecol. 2019; 40(7):918-924. DOI: 10.1080/01443615.2019.1673709. View

12.

Gunderson E, Quesenberry Jr C, Ning X, Jacobs Jr D, Gross M, Goff Jr D . Lactation Duration and Midlife Atherosclerosis. Obstet Gynecol. 2015; 126(2):381-390. PMC: 5193138. DOI: 10.1097/AOG.0000000000000919. View

13.

Iwama N, Sugiyama T, Metoki H, Saito M, Hoshiai T, Watanabe Z . Associations between glycosylated hemoglobin level at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan: The Japan Environment and Children's Study (JECS). Diabetes Res Clin Pract. 2020; 169:108377. DOI: 10.1016/j.diabres.2020.108377. View

14.

Yokoyama Y, Takachi R, Ishihara J, Ishii Y, Sasazuki S, Sawada N . Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area. J Epidemiol. 2016; 26(8):420-32. PMC: 4967663. DOI: 10.2188/jea.JE20150064. View

15.

Michikawa T, Nitta H, Nakayama S, Yamazaki S, Isobe T, Tamura K . Baseline Profile of Participants in the Japan Environment and Children's Study (JECS). J Epidemiol. 2017; 28(2):99-104. PMC: 5792233. DOI: 10.2188/jea.JE20170018. View

16.

Butte N . Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus. Am J Clin Nutr. 2000; 71(5 Suppl):1256S-61S. DOI: 10.1093/ajcn/71.5.1256s. View

17.

Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M . Rationale and study design of the Japan environment and children's study (JECS). BMC Public Health. 2014; 14:25. PMC: 3893509. DOI: 10.1186/1471-2458-14-25. View

18.

Michikawa T, Nitta H, Nakayama S, Ono M, Yonemoto J, Tamura K . The Japan Environment and Children's Study (JECS): A Preliminary Report on Selected Characteristics of Approximately 10 000 Pregnant Women Recruited During the First Year of the Study. J Epidemiol. 2015; 25(6):452-8. PMC: 4444500. DOI: 10.2188/jea.JE20140186. View

19.

Jayalekshmi V, Ramachandran S . Maternal cholesterol levels during gestation: boon or bane for the offspring?. Mol Cell Biochem. 2020; 476(1):401-416. DOI: 10.1007/s11010-020-03916-2. View

20.

Yamamoto-Hanada K, Yang L, Ishitsuka K, Ayabe T, Mezawa H, Konishi M . Allergic profiles of mothers and fathers in the Japan Environment and Children's Study (JECS): a nationwide birth cohort study. World Allergy Organ J. 2017; 10(1):24. PMC: 5545861. DOI: 10.1186/s40413-017-0157-0. View