Applications of Antimicrobial Photodynamic Therapy Against Bacterial Biofilms

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Mar 25

PMID 35328629

Authors

Sandile Phinda Songca

Yaw Adjei

Affiliations

Soon will be listed here.

Abstract

Antimicrobial photodynamic therapy and allied photodynamic antimicrobial chemotherapy have shown remarkable activity against bacterial pathogens in both planktonic and biofilm forms. There has been little or no resistance development against antimicrobial photodynamic therapy. Furthermore, recent developments in therapies that involve antimicrobial photodynamic therapy in combination with photothermal hyperthermia therapy, magnetic hyperthermia therapy, antibiotic chemotherapy and cold atmospheric pressure plasma therapy have shown additive and synergistic enhancement of its efficacy. This paper reviews applications of antimicrobial photodynamic therapy and non-invasive combination therapies often used with it, including sonodynamic therapy and nanozyme enhanced photodynamic therapy. The antimicrobial and antibiofilm mechanisms are discussed. This review proposes that these technologies have a great potential to overcome the bacterial resistance associated with bacterial biofilm formation.

Citing Articles

Photodynamic therapy in non-surgical treatment of periodontitis.

Maj A, Kusiak A, Garbacz K, Cichonska D, Swietlik D Sci Rep. 2025; 15(1):5903.

PMID: 39966437 PMC: 11836360. DOI: 10.1038/s41598-025-89563-3.

Enhancing the Photocatalytic Efficacy of g-CN Through Irradiation Modification and Composite Construction with TiC for Photodynamic Therapy.

Huang B, Wang Y, Chen X, Wu Y, Xu K, Xie S Molecules. 2025; 30(3).

PMID: 39942591 PMC: 11820621. DOI: 10.3390/molecules30030487.

Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria.

Pei L, Yu X, Shan X, Li G Future Med Chem. 2025; 17(4):467-484.

PMID: 39878538 PMC: 11834427. DOI: 10.1080/17568919.2025.2458459.

Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention.

Azeem K, Fatima S, Ali A, Ubaid A, Husain F, Abid M Life (Basel). 2025; 15(1).

PMID: 39859989 PMC: 11767195. DOI: 10.3390/life15010049.

Exploring the application of herbal photosensitizers in antimicrobial photodynamic therapy against .

Virdi V, Singh J, Sharma R, Verma D 3 Biotech. 2025; 15(2):48.

PMID: 39845929 PMC: 11747057. DOI: 10.1007/s13205-024-04205-1.

References

Martins Antunes de Melo W, Celiesiute-Germaniene R, Simonis P, Stirke A . Antimicrobial photodynamic therapy (aPDT) for biofilm treatments. Possible synergy between aPDT and pulsed electric fields. Virulence. 2021; 12(1):2247-2272. PMC: 8437467. DOI: 10.1080/21505594.2021.1960105. View

Karygianni L, Ren Z, Koo H, Thurnheer T . Biofilm Matrixome: Extracellular Components in Structured Microbial Communities. Trends Microbiol. 2020; 28(8):668-681. DOI: 10.1016/j.tim.2020.03.016. View

Sabino C, Wainwright M, Ribeiro M, Sellera F, Dos Anjos C, Baptista M . Global priority multidrug-resistant pathogens do not resist photodynamic therapy. J Photochem Photobiol B. 2020; 208:111893. DOI: 10.1016/j.jphotobiol.2020.111893. View

Canti G, Calastretti A, Bevilacqua A, Reddi E, Palumbo G, Nicolin A . Combination of photodynamic therapy + immunotherapy + chemotherapy in murine leukiemia. Neoplasma. 2010; 57(2):184-8. DOI: 10.4149/neo_2010_02_184. View

Pourhajibagher M, Bahador A . Adjunctive antimicrobial photodynamic therapy to conventional chemo-mechanical debridement of infected root canal systems: A systematic review and meta-analysis. Photodiagnosis Photodyn Ther. 2019; 26:19-26. DOI: 10.1016/j.pdpdt.2019.02.009. View

Roy J, Pandey V, Gupta I, Shekhar H . Antibacterial Sonodynamic Therapy: Current Status and Future Perspectives. ACS Biomater Sci Eng. 2021; 7(12):5326-5338. DOI: 10.1021/acsbiomaterials.1c00587. View

Wei G, Yang G, Wang Y, Jiang H, Fu Y, Yue G . Phototherapy-based combination strategies for bacterial infection treatment. Theranostics. 2020; 10(26):12241-12262. PMC: 7667673. DOI: 10.7150/thno.52729. View

Di Corato R, Bealle G, Kolosnjaj-Tabi J, Espinosa A, Clement O, Silva A . Combining magnetic hyperthermia and photodynamic therapy for tumor ablation with photoresponsive magnetic liposomes. ACS Nano. 2015; 9(3):2904-16. DOI: 10.1021/nn506949t. View

Luksiene Z, Kalvelyte A, Supino R . On the combination of photodynamic therapy with ionizing radiation. J Photochem Photobiol B. 2000; 52(1-3):35-42. DOI: 10.1016/s1011-1344(99)00098-6. View

10.

Wainwright M . Photodynamic antimicrobial chemotherapy (PACT). J Antimicrob Chemother. 1998; 42(1):13-28. DOI: 10.1093/jac/42.1.13. View

11.

Barra F, Roscetto E, Soriano A, Vollaro A, Postiglione I, Pierantoni G . Photodynamic and Antibiotic Therapy in Combination to Fight Biofilms and Resistant Surface Bacterial Infections. Int J Mol Sci. 2015; 16(9):20417-30. PMC: 4613211. DOI: 10.3390/ijms160920417. View

12.

Hughes G, Webber M . Novel approaches to the treatment of bacterial biofilm infections. Br J Pharmacol. 2017; 174(14):2237-2246. PMC: 5481657. DOI: 10.1111/bph.13706. View

13.

Feng J, Lamour G, Xue R, Mirvakliki M, Hatzikiriakos S, Xu J . Chemical, physical and morphological properties of bacterial biofilms affect survival of encased Campylobacter jejuni F38011 under aerobic stress. Int J Food Microbiol. 2016; 238:172-182. DOI: 10.1016/j.ijfoodmicro.2016.09.008. View

14.

Sadanala K, Chaturvedi P, Seo Y, Kim J, Jo Y, Lee Y . Sono-photodynamic combination therapy: a review on sensitizers. Anticancer Res. 2014; 34(9):4657-64. View

15.

Guo J, Xu Y, Liu M, Yu J, Yang H, Lei W . An MSN-based synergistic nanoplatform for root canal biofilm eradication Fenton-enhanced sonodynamic therapy. J Mater Chem B. 2021; 9(37):7686-7697. DOI: 10.1039/d1tb01031j. View

16.

Brovko L, Meyer A, Tiwana A, Chen W, Liu H, Filipe C . Photodynamic treatment: a novel method for sanitation of food handling and food processing surfaces. J Food Prot. 2009; 72(5):1020-4. DOI: 10.4315/0362-028x-72.5.1020. View

17.

Luke-Marshall N, Hansen L, Shafirstein G, Campagnari A . Antimicrobial Photodynamic Therapy with Chlorin e6 Is Bactericidal against Biofilms of the Primary Human Otopathogens. mSphere. 2020; 5(4). PMC: 7364218. DOI: 10.1128/mSphere.00492-20. View

18.

Pang X, Li D, Zhu J, Cheng J, Liu G . Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics. Nanomicro Lett. 2021; 12(1):144. PMC: 7770670. DOI: 10.1007/s40820-020-00485-3. View

19.

Gneveckow U, Jordan A, Scholz R, Bruss V, Waldofner N, Ricke J . Description and characterization of the novel hyperthermia- and thermoablation-system MFH 300F for clinical magnetic fluid hyperthermia. Med Phys. 2004; 31(6):1444-51. DOI: 10.1118/1.1748629. View

20.

Huang L, Xuan Y, Koide Y, Zhiyentayev T, Tanaka M, Hamblin M . Type I and Type II mechanisms of antimicrobial photodynamic therapy: an in vitro study on gram-negative and gram-positive bacteria. Lasers Surg Med. 2012; 44(6):490-9. PMC: 3428129. DOI: 10.1002/lsm.22045. View