On the Efficacy of ZnO Nanostructures Against SARS-CoV-2

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Mar 25

PMID 35328455

Authors

Maria Chiara Sportelli

Margherita Izzi

Daniela Loconsole

Anna Sallustio

Rosaria Anna Picca

Roberto Felici

Maria Chironna

Nicola Cioffi

Affiliations

Soon will be listed here.

Abstract

In 2019, the new coronavirus disease (COVID-19), related to the severe acute respiratory syndrome coronavirus (SARS-CoV-2), started spreading around the word, giving rise to the world pandemic we are still facing. Since then, many strategies for the prevention and control of COVID-19 have been studied and implemented. In addition to pharmacological treatments and vaccines, it is mandatory to ensure the cleaning and disinfection of the skin and inanimate surfaces, especially in those contexts where the contagion could spread quickly, such as hospitals and clinical laboratories, schools, transport, and public places in general. Here, we report the efficacy of ZnO nanoparticles (ZnONPs) against SARS-CoV-2. NPs were produced using an ecofriendly method and fully characterized; their antiviral activity was tested in vitro against SARS-CoV-2, showing a decrease in viral load between 70% and 90%, as a function of the material's composition. Application of these nano-antimicrobials as coatings for commonly touched surfaces is envisaged.

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References

Rahman M, Idid S . Can Zn Be a Critical Element in COVID-19 Treatment?. Biol Trace Elem Res. 2020; 199(2):550-558. PMC: 7250542. DOI: 10.1007/s12011-020-02194-9. View

Ye S, Shao K, Li Z, Guo N, Zuo Y, Li Q . Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and Charge Matter. ACS Appl Mater Interfaces. 2015; 7(38):21571-9. DOI: 10.1021/acsami.5b06876. View

Apicella A, Cappello B, Del Nobile M, La Rotonda M, Mensitieri G, Nicolais L . Poly(ethylene oxide) (PEO) and different molecular weight PEO blends monolithic devices for drug release. Biomaterials. 1993; 14(2):83-90. DOI: 10.1016/0142-9612(93)90215-n. View

Skalny A, Rink L, Ajsuvakova O, Aschner M, Gritsenko V, Alekseenko S . Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review). Int J Mol Med. 2020; 46(1):17-26. PMC: 7255455. DOI: 10.3892/ijmm.2020.4575. View

Sabel C, Neureuther J, Siemann S . A spectrophotometric method for the determination of zinc, copper, and cobalt ions in metalloproteins using Zincon. Anal Biochem. 2009; 397(2):218-26. DOI: 10.1016/j.ab.2009.10.037. View

Kang S, Yang M, Hong Z, Zhang L, Huang Z, Chen X . Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharm Sin B. 2020; 10(7):1228-1238. PMC: 7194921. DOI: 10.1016/j.apsb.2020.04.009. View

Sportelli M, Picca R, Izzi M, Palazzo G, Gristina R, Innocenti M . ZnO Nanostructures with Antibacterial Properties Prepared by a Green Electrochemical-Thermal Approach. Nanomaterials (Basel). 2020; 10(3). PMC: 7153254. DOI: 10.3390/nano10030473. View

Carmona F, Dal Sasso G, Bertolotti F, Ramirez-Rodriguez G, Delgado-Lopez J, Pedersen J . The role of nanoparticle structure and morphology in the dissolution kinetics and nutrient release of nitrate-doped calcium phosphate nanofertilizers. Sci Rep. 2020; 10(1):12396. PMC: 7382453. DOI: 10.1038/s41598-020-69279-2. View

Abo-Zeid Y, Ismail N, McLean G, Hamdy N . A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection. Eur J Pharm Sci. 2020; 153:105465. PMC: 7354764. DOI: 10.1016/j.ejps.2020.105465. View

10.

Monette A, Mouland A . Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates. Viruses. 2020; 12(10). PMC: 7589941. DOI: 10.3390/v12101179. View

11.

Groneberg D, Heppt W, Cryer A, Wussow A, Peiser C, Zweng M . Toxic rhinitis-induced changes of human nasal mucosa innervation. Toxicol Pathol. 2003; 31(3):326-31. DOI: 10.1080/01926230390204379. View

12.

Tavakoli A, Ataei-Pirkooh A, Mm Sadeghi G, Bokharaei-Salim F, Sahrapour P, Kiani S . Polyethylene glycol-coated zinc oxide nanoparticle: an efficient nanoweapon to fight against herpes simplex virus type 1. Nanomedicine (Lond). 2018; 13(21):2675-2690. DOI: 10.2217/nnm-2018-0089. View

13.

Sportelli M, Izzi M, Kukushkina E, Hossain S, Picca R, Ditaranto N . Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2?. Nanomaterials (Basel). 2020; 10(4). PMC: 7221591. DOI: 10.3390/nano10040802. View

14.

Ruiz-Hitzky E, Darder M, Wicklein B, Ruiz-Garcia C, Martin-Sampedro R, Del Real G . Nanotechnology Responses to COVID-19. Adv Healthc Mater. 2020; 9(19):e2000979. DOI: 10.1002/adhm.202000979. View

15.

Sanches L, Petri D, Carrasco L, Carmona-Ribeiro A . The antimicrobial activity of free and immobilized poly (diallyldimethylammonium) chloride in nanoparticles of poly (methylmethacrylate). J Nanobiotechnology. 2015; 13:58. PMC: 4582890. DOI: 10.1186/s12951-015-0123-3. View

16.

Ghaffari H, Tavakoli A, Moradi A, Tabarraei A, Bokharaei-Salim F, Zahmatkeshan M . Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: another emerging application of nanomedicine. J Biomed Sci. 2019; 26(1):70. PMC: 6734352. DOI: 10.1186/s12929-019-0563-4. View

17.

LaForce F, Boose D . Effect of zinc and phosphate on an antibacterial peptide isolated from lung lavage. Infect Immun. 1984; 45(3):692-6. PMC: 263351. DOI: 10.1128/iai.45.3.692-696.1984. View

18.

McPherson S, Keunen J, Bird A, Chew E, van Kuijk F . Investigate Oral Zinc as a Prophylactic Treatment for Those at Risk for COVID-19. Am J Ophthalmol. 2020; 216:A5-A6. PMC: 7247979. DOI: 10.1016/j.ajo.2020.04.028. View

19.

Pormohammad A, Monych N, Turner R . Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes. Int J Mol Med. 2020; 47(1):326-334. PMC: 7723401. DOI: 10.3892/ijmm.2020.4790. View

20.

Read S, Obeid S, Ahlenstiel C, Ahlenstiel G . The Role of Zinc in Antiviral Immunity. Adv Nutr. 2019; 10(4):696-710. PMC: 6628855. DOI: 10.1093/advances/nmz013. View