The Effect of the Tumor Microenvironment on Lymphoid Neoplasms Derived from B Cells

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2022 Mar 25

PMID 35328127

Authors

Giuseppe Ingravallo

Roberto Tamma

Giuseppina Opinto

Tiziana Annese

Francesco Gaudio

Giorgina Specchia

Tommasina Perrone

Pellegrino Musto

Gerardo Cazzato

Emilio Bellitti

Saverio Capodiferro

Eugenio Maiorano

Domenico Ribatti

Affiliations

Soon will be listed here.

Abstract

Lymphomas are characteristic tumors surrounded by an inflammatory microenvironment. The cells of the microenvironment are essential for the growth and survival of neoplastic cells and are recruited through the effect of cytokines/chemokines. Lymphomas include heterogeneous groups of neoplasms infiltrating various lymphoid structures which may arise from B lymphocytes, T lymphocytes, and natural killer (NK) cells at various stages of their differentiation state. In this review article, we analyze the literature data concerning the involvement of the tumor microenvironment (TME) in the progression of lymphomas and the recent advances in the analysis of microenvironment components in the most common forms: some mature B cell lymphoma neoplasms and classic Hodgkin lymphomas. The complex crosstalk between the TME and tumor cells led to the discovery of many mechanisms usable as molecular-targeted therapy through the control of diverse elements of the TME, varying from inhibitors of angiogenic cytokines and their receptors to the regulation of cells' activities and the novel immune checkpoint inhibitors.

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