Preeclampsia and Cerebral Palsy in Offspring

Overview

Journal Children (Basel)

Specialty Health Services

Date 2022 Mar 25

PMID 35327757

Authors

Miltiadis Badagionis

Theodoros N Sergentanis

Panagiota Pervanidou

Emmanouil Kalampokas

Nikolaos Vlahos

Makarios Eleftheriades

Affiliations

Soon will be listed here.

Abstract

The aim of this systematic review and meta-analysis is to examine the association between exposure to preeclampsia during pregnancy and the occurrence of cerebral palsy in offspring. For this reason, the authors searched PubMed/Medline, EMBASE, and Google Scholar databases (end-of-search: 22 November 2021) and identified the most relevant studies. Then, a meta-analysis of all the eligible studies was performed. Subgroup and meta-regression analyses by study design, degree of adjustment, and geographical region were also conducted. A total of 10 studies were finally included, and no statistical significance was noted in the association between preeclampsia and cerebral palsy (pooled OR = 1.16, 95% CI: 0.77-1.74). The subgroup of studies that provided adjusted odds ratios for any variable except for gestational age showed a statistically significant association (pooled OR = 1.62, 95% CI: 1.36-1.93), whereas the association dissipated in studies also adjusting for gestational age (pooled OR = 1.63, 95% CI: 0.48-5.50). In conclusion, it seems that preeclampsia is not associated with cerebral palsy independently of gestational age; however, further research is needed to shed light on this topic.

Citing Articles

Cerebral Palsy and Motor Impairment After Extreme Prematurity: Prediction of Diagnoses at Ages 2 and 10 Years.

Marinelli T, Yi J, OShea T, Joseph R, Hooper S, Kuban K J Pediatr. 2024; 271:114037.

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Risk factors and glycaemic control in small-for-gestational-age infants born to mothers with gestational diabetes mellitus: a case-control study using propensity score matching based on a large population.

Li J, Pan Y, Zheng Q, Chen X, Jiang X, Liu R BMJ Open. 2024; 14(1):e078325.

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Genetic pathways in cerebral palsy: a review of the implications for precision diagnosis and understanding disease mechanisms.

Xu Y, Li Y, Richard S, Sun Y, Zhu C Neural Regen Res. 2023; 19(7):1499-1508.

PMID: 38051892 PMC: 10883492. DOI: 10.4103/1673-5374.385855.

Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature.

Koulouraki S, Paschos V, Pervanidou P, Christopoulos P, Gerede A, Eleftheriades M Children (Basel). 2023; 10(5).

PMID: 37238374 PMC: 10216976. DOI: 10.3390/children10050826.

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