Model for Studying Gut Microbiota in Behaviors and Neurodegenerative Diseases

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2022 Mar 25

PMID 35327401

Authors

Meng-Hsuan Chiang

Shuk-Man Ho

Hui-Yu Wu

Yu-Chun Lin

Wan-Hua Tsai

Tony Wu

Chih-Ho Lai

Chia-Lin Wu

Affiliations

Soon will be listed here.

Abstract

Mounting evidence indicates that the gut microbiota is linked to several physiological processes and disease development in mammals; however, the underlying mechanisms remained unexplored mostly due to the complexity of the mammalian gut microbiome. The fruit fly, , is a valuable animal model for studying host-gut microbiota interactions in translational aspects. The availability of powerful genetic tools and resources in allowed the scientists to unravel the mechanisms by which the gut microbes affect fitness, health, and behavior of their hosts. models have been extensively used not only to study animal behaviors (i.e., courtship, aggression, sleep, and learning & memory), but also some human related neurodegenerative diseases (i.e., Alzheimer's disease and Parkinson's disease) in the past. This review comprehensively summarizes the current understanding of the gut microbiota of and its impact on fly behavior, physiology, and neurodegenerative diseases.

Citing Articles

Different Long-Term Nutritional Regimens of Shape Its Microbiota and Associated Metabolic Activity in a Sex-Specific Manner.

Jelena R, Jelena T, Marija R, Tanja L, Tatjana S, Bojan B Insects. 2025; 16(2).

PMID: 40003771 PMC: 11856610. DOI: 10.3390/insects16020141.

The Neural Correlations of Olfactory Associative Reward Memories in .

Lin Y, Wu T, Wu C Cells. 2024; 13(20.

PMID: 39451234 PMC: 11506542. DOI: 10.3390/cells13201716.

Time-restricted feeding mediated modulation of microbiota leads to changes in muscle physiology in Drosophila obesity models.

Livelo C, Guo Y, Madhanagopal J, Morrow C, Melkani G Aging Cell. 2024; 24(2):e14382.

PMID: 39446089 PMC: 11822661. DOI: 10.1111/acel.14382.

Unveiling the Brazilian kefir microbiome: discovery of a novel Lactobacillus kefiranofaciens (LkefirU) genome and in silico prospection of bioactive peptides with potential anti-Alzheimer properties.

Silva M, Batista L, Malta S, Santos A, Mendes-Silva A, Bonetti A BMC Genomics. 2024; 25(1):884.

PMID: 39304820 PMC: 11414172. DOI: 10.1186/s12864-024-10695-3.

Probiotic spp. improves memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons.

Ho S, Tsai W, Lai C, Chiang M, Lee W, Wu H Gut Microbes. 2024; 16(1):2316533.

PMID: 38372783 PMC: 10877976. DOI: 10.1080/19490976.2024.2316533.

References

Logsdon A, Erickson M, Rhea E, Salameh T, Banks W . Gut reactions: How the blood-brain barrier connects the microbiome and the brain. Exp Biol Med (Maywood). 2017; 243(2):159-165. PMC: 5788145. DOI: 10.1177/1535370217743766. View

Lee H, Lee S, Lee J, Lee W, Min K . The role of commensal microbes in the lifespan of . Aging (Albany NY). 2019; 11(13):4611-4640. PMC: 6660043. DOI: 10.18632/aging.102073. View

Tian Y, Zhang Z, Han J . Drosophila Studies on Autism Spectrum Disorders. Neurosci Bull. 2017; 33(6):737-746. PMC: 5725381. DOI: 10.1007/s12264-017-0166-6. View

Batista L, Malta S, Silva H, Borges L, Rocha L, da Silva J . Kefir metabolites in a fly model for Alzheimer's disease. Sci Rep. 2021; 11(1):11262. PMC: 8160324. DOI: 10.1038/s41598-021-90749-8. View

Melzer D, Pilling L, Ferrucci L . The genetics of human ageing. Nat Rev Genet. 2019; 21(2):88-101. PMC: 9934000. DOI: 10.1038/s41576-019-0183-6. View

Montague S, Baker B . Memory Elicited by Courtship Conditioning Requires Mushroom Body Neuronal Subsets Similar to Those Utilized in Appetitive Memory. PLoS One. 2016; 11(10):e0164516. PMC: 5072562. DOI: 10.1371/journal.pone.0164516. View

Schwaerzel M, Monastirioti M, Scholz H, Friggi-Grelin F, Birman S, Heisenberg M . Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila. J Neurosci. 2003; 23(33):10495-502. PMC: 6740930. View

Scandaglia M, Lopez-Atalaya J, Medrano-Fernandez A, Lopez-Cascales M, Del Blanco B, Lipinski M . Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons. Cell Rep. 2017; 21(1):47-59. PMC: 5679733. DOI: 10.1016/j.celrep.2017.09.014. View

Ricciarelli R, Fedele E . The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind. Curr Neuropharmacol. 2017; 15(6):926-935. PMC: 5652035. DOI: 10.2174/1570159X15666170116143743. View

10.

Wu S, Cao Z, Chang K, Juang J . Intestinal microbial dysbiosis aggravates the progression of Alzheimer's disease in Drosophila. Nat Commun. 2017; 8(1):24. PMC: 5478647. DOI: 10.1038/s41467-017-00040-6. View

11.

Lin S, Owald D, Chandra V, Talbot C, Huetteroth W, Waddell S . Neural correlates of water reward in thirsty Drosophila. Nat Neurosci. 2014; 17(11):1536-42. PMC: 4213141. DOI: 10.1038/nn.3827. View

12.

van Houte S, Ekroth A, Broniewski J, Chabas H, Ashby B, Bondy-Denomy J . The diversity-generating benefits of a prokaryotic adaptive immune system. Nature. 2016; 532(7599):385-8. PMC: 4935084. DOI: 10.1038/nature17436. View

13.

Paroni G, Bisceglia P, Seripa D . Understanding the Amyloid Hypothesis in Alzheimer's Disease. J Alzheimers Dis. 2019; 68(2):493-510. DOI: 10.3233/JAD-180802. View

14.

Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M . G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 2002; 16(14):1779-91. PMC: 186403. DOI: 10.1101/gad.989402. View

15.

Delbare S, Ahmed-Braimah Y, Wolfner M, Clark A . Interactions between the microbiome and mating influence the female's transcriptional profile in Drosophila melanogaster. Sci Rep. 2020; 10(1):18168. PMC: 7584617. DOI: 10.1038/s41598-020-75156-9. View

16.

Carr J, LeBlanc L . Autism spectrum disorders in early childhood: an overview for practicing physicians. Prim Care. 2007; 34(2):343-59. DOI: 10.1016/j.pop.2007.04.009. View

17.

Mis J, Ner S, Grigliatti T . Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing. Mol Genet Genomics. 2006; 275(6):513-26. DOI: 10.1007/s00438-006-0116-x. View

18.

Selkrig J, Mohammad F, Ng S, Chua J, Tumkaya T, Ho J . The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors. Sci Rep. 2018; 8(1):10646. PMC: 6045657. DOI: 10.1038/s41598-018-28764-5. View

19.

Matthews D, Jenks S . Ingestion of Mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice. Behav Processes. 2013; 96:27-35. DOI: 10.1016/j.beproc.2013.02.007. View

20.

Shyu W, Chiu T, Chiang M, Cheng Y, Tsai Y, Fu T . Neural circuits for long-term water-reward memory processing in thirsty Drosophila. Nat Commun. 2017; 8:15230. PMC: 5440665. DOI: 10.1038/ncomms15230. View