Overview of the Clinical and Molecular Features of Legionella Pneumophila: Focus on Novel Surveillance and Diagnostic Strategies

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2022 Mar 25

PMID 35326833

Authors

Giuseppe Gattuso

Roberta Rizzo

Alessandro Lavoro

Vincenzoleo Spoto

Giuseppe Porciello

Concetta Montagnese

Diana Cina

Alessia Cosentino

Cinzia Lombardo

Maria Lina Mezzatesta

Mario Salmeri

Affiliations

Soon will be listed here.

Abstract

() is one of the most threatening nosocomial pathogens. The implementation of novel and more effective surveillance and diagnostic strategies is mandatory to prevent the occurrence of legionellosis outbreaks in hospital environments. On these bases, the present review is aimed to describe the main clinical and molecular features of focusing attention on the latest findings on drug resistance mechanisms. In addition, a detailed description of the current guidelines for the disinfection and surveillance of the water systems is also provided. Finally, the diagnostic strategies available for the detection of spp. were critically reviewed, paying the attention to the description of the culture, serological and molecular methods as well as on the novel high-sensitive nucleic acid amplification systems, such as droplet digital PCR.

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