Stroke Genomics: Current Knowledge, Clinical Applications and Future Possibilities

Overview

Journal Brain Sci

Publisher MDPI

Date 2022 Mar 25

PMID 35326259

Authors

Sandeep Appunni

Muni Rubens

Venkataraghavan Ramamoorthy

Anshul Saxena

Peter McGranaghan

Emir Veledar

Affiliations

Soon will be listed here.

Abstract

The pathophysiology of stoke involves many complex pathways and risk factors. Though there are several ongoing studies on stroke, treatment options are limited, and the prevalence of stroke is continuing to increase. Understanding the genomic variants and biological pathways associated with stroke could offer novel therapeutic alternatives in terms of drug targets and receptor modulations for newer treatment methods. It is challenging to identify individual causative mutations in a single gene because many alleles are responsible for minor effects. Therefore, multiple factorial analyses using single nucleotide polymorphisms (SNPs) could be used to gain new insight by identifying potential genetic risk factors. There are many studies, such as Genome-Wide Association Studies (GWAS) and Phenome-Wide Association Studies (PheWAS) which have identified numerous independent loci associated with stroke, which could be instrumental in developing newer drug targets and novel therapies. Additionally, using analytical techniques, such as meta-analysis and Mendelian randomization could help in evaluating stroke risk factors and determining treatment priorities. Combining SNPs into polygenic risk scores and lifestyle risk factors could detect stroke risk at a very young age and help in administering preventive interventions.

Citing Articles

Multidimensional Approach of Genotype and Phenotype in Stroke Etiology: The MAGPIE Study.

Ranjan R, Adhikary D, Barman S, Islam M, Ken-Dror G, Yusuf M Health Sci Rep. 2024; 7(12):e70227.

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Systems-level computational modeling in ischemic stroke: from cells to patients.

Li G, Zhao Y, Ma W, Gao Y, Zhao C Front Physiol. 2024; 15:1394740.

PMID: 39015225 PMC: 11250596. DOI: 10.3389/fphys.2024.1394740.

Polymorphism of , the gene encoding a heat-resistant obscure (Hero) protein with chaperone activity, is a novel link in ischemic stroke.

Belykh A, Soldatov V, Stetskaya T, Kobzeva K, Soldatova M, Polonikov A IBRO Neurosci Rep. 2023; 14:453-461.

PMID: 37252629 PMC: 10209486. DOI: 10.1016/j.ibneur.2023.05.004.

Association of C-reactive protein gene polymorphisms with the risk of ischemic stroke: A systematic review and meta-analysis.

Chen W, Zhu X, Hu Y, Hong H, Kuang L, Liang N Brain Behav. 2023; 13(6):e2976.

PMID: 37221147 PMC: 10275524. DOI: 10.1002/brb3.2976.

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