[Research Advances on the Application of Stem Cells in Sweat Gland Regeneration]

Overview

Journal Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi

Date 2022 Mar 24

PMID 35325977

Authors

J J Zhang

M Y Wang

J Zhao

D Y Jiang

Affiliations

Soon will be listed here.

Abstract

Sweat gland is one of the important appendage organs of the skin, which plays an important role in thermoregulation and homeostasis maintenance. Sweat glands are damaged and unable to self-repair after burns, resulting in perspiration disorders eventually. However, current clinical strategies cannot restore the function of the damaged sweat glands effectively. Therefore, it is urgent to seek treatments that can promote the regeneration of sweat glands and restore their normal functions. Stem cells have extensive sources, low immunogenicity, high proliferation capacity, and multi-directional differentiation potential, which have become a focus in the field of regenerative medicine. In recent years, a variety of stem cells have been induced to differentiate into sweat gland-like tissue with certain secretory function, which provides treatment direction for sweat gland regeneration after burns in clinic. This article reviews the recent research advances on the application of stem cells in sweat gland regeneration from the perspectives of the manner by which stem cells transform into sweat gland cells in different environments and their influencing factors.

Citing Articles

An Overview of Recent Developments in the Management of Burn Injuries.

Radzikowska-Buchner E, Lopuszynska I, Flieger W, Tobiasz M, Maciejewski R, Flieger J Int J Mol Sci. 2023; 24(22).

PMID: 38003548 PMC: 10671630. DOI: 10.3390/ijms242216357.

[Research advances on the regulatory mechanism of sweat secretion ion channels of eccrine sweat glands].

Shen J, Xu Y Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022; 38(8):794-798.

PMID: 36058703 PMC: 11705564. DOI: 10.3760/cma.j.cn501120-20210517-00191.

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