Burden of Oral Cancer in Asia from 1990 to 2019: Estimates from the Global Burden of Disease 2019 Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2022 Mar 24

PMID 35324990

Authors

Long Xie

Zhengjun Shang

Affiliations

Soon will be listed here.

Abstract

Background: Oral cancer (OC) poses a threat to human health and imposes a heavy burden on countries. We assessed the burden imposed by OC on Asian nations from 1990 to 2019 based on gender and age.

Methods: We collected oral cancer data from the 2019 Global Burden of Disease study from 1990 to 2019 in 45 Asian countries and territories. Annual case data and age-standardised rates (ASRs) were used to investigate the incidence, mortality, and disability-adjusted life-years (DALYs) of OC based on age and gender from 1990 to 2019 in 45 Asian countries and territories. Estimated annual percentage changes (EAPCs) were used to assess incidence rate, mortality, and trends in DALYs.

Results: The age-standardised incidence rate (ASIR) of OC increased from 1990 to 2019 with an EAPC of 0.32 (95% CI, 0.19-0.46), and the age-standardised death rate of OC remained stable at an EAPC of 0.08 (95%CI, from -0.06 to 0.21). The age-standardised DALYs of OC decreased at an EAPC of -0.16 (95%CI, from -0.30 to -0.02). The proportion of patients older than 70 years increased yearly in terms of incidence, mortality, and DALYs from 1990 to 2019. Of the DALYs, smoking was the main contributor in the Asian regions, and the largest contributor to DALYs in most Asian regions. Other contributors were alcohol use and chewing tobacco.

Conclusion: Although the burden of OC was declining in Asia, South Asia remained the region with the highest burden. OC caused the greatest burden in Pakistan, Taiwan China, and India. Therefore, measures should be taken to reduce the burden of oral cancer in high-risk regions and countries with attributable risk factors.

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References

Ren Z, Hu C, He H, Li Y, Lyu J . Global and regional burdens of oral cancer from 1990 to 2017: Results from the global burden of disease study. Cancer Commun (Lond). 2020; 40(2-3):81-92. PMC: 7163731. DOI: 10.1002/cac2.12009. View

Fu Q, Chen Y, Li Z, Jing Q, Hu C, Liu H . A deep learning algorithm for detection of oral cavity squamous cell carcinoma from photographic images: A retrospective study. EClinicalMedicine. 2020; 27:100558. PMC: 7599313. DOI: 10.1016/j.eclinm.2020.100558. View

Al-Jaber A, Al-Nasser L, El-Metwally A . Epidemiology of oral cancer in Arab countries. Saudi Med J. 2016; 37(3):249-55. PMC: 4800887. DOI: 10.15537/smj.2016.3.11388. View

Kadashetti V, Chaudhary M, Patil S, Gawande M, Shivakumar K, Patil S . Analysis of various risk factors affecting potentially malignant disorders and oral cancer patients of Central India. J Cancer Res Ther. 2015; 11(2):280-6. DOI: 10.4103/0973-1482.151417. View

Hankey B, Ries L, Kosary C, Feuer E, Merrill R, Clegg L . Partitioning linear trends in age-adjusted rates. Cancer Causes Control. 2000; 11(1):31-5. DOI: 10.1023/a:1008953201688. View

Chuang S, Su W, Chen S, Yen A, Wang C, Fann J . Population-based screening program for reducing oral cancer mortality in 2,334,299 Taiwanese cigarette smokers and/or betel quid chewers. Cancer. 2017; 123(9):1597-1609. DOI: 10.1002/cncr.30517. View

Parkin D, Bray F, Ferlay J, Pisani P . Global cancer statistics, 2002. CA Cancer J Clin. 2005; 55(2):74-108. DOI: 10.3322/canjclin.55.2.74. View

Amarasinghe H, Jayasinghe R, Dharmagunawardene D, Attygalla M, Scuffham P, Johnson N . Economic burden of managing oral cancer patients in Sri Lanka: a cross-sectional hospital -based costing study. BMJ Open. 2019; 9(7):e027661. PMC: 6661677. DOI: 10.1136/bmjopen-2018-027661. View

Dantas T, Barros Silva P, Sousa E, da Cunha M, de Aguiar A, Costa F . Influence of Educational Level, Stage, and Histological Type on Survival of Oral Cancer in a Brazilian Population: A Retrospective Study of 10 Years Observation. Medicine (Baltimore). 2016; 95(3):e2314. PMC: 4998238. DOI: 10.1097/MD.0000000000002314. View

10.

Csikar J, Aravani A, Godson J, Day M, Wilkinson J . Incidence of oral cancer among South Asians and those of other ethnic groups by sex in West Yorkshire and England, 2001-2006. Br J Oral Maxillofac Surg. 2012; 51(1):25-9. DOI: 10.1016/j.bjoms.2012.03.008. View

11.

Albar M . Islamic teachings and cancer prevention. J Family Community Med. 2012; 1(1):79-86. PMC: 3437186. View

12.

Mills A . Health care systems in low- and middle-income countries. N Engl J Med. 2014; 370(6):552-7. DOI: 10.1056/NEJMra1110897. View

13.

Warnakulasuriya S . Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2008; 45(4-5):309-16. DOI: 10.1016/j.oraloncology.2008.06.002. View

14.

Ye L, Jiang Y, Liu W, Tao H . Correlation between periodontal disease and oral cancer risk: A meta-analysis. J Cancer Res Ther. 2017; 12(Supplement):C237-C240. DOI: 10.4103/0973-1482.200746. View

15.

Fitzmaurice C, Allen C, Barber R, Barregard L, Bhutta Z, Brenner H . Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2016; 3(4):524-548. PMC: 6103527. DOI: 10.1001/jamaoncol.2016.5688. View

16.

Bai X, Zhang J, Wei L . Analysis of primary oral and oropharyngeal squamous cell carcinoma in inhabitants of Beijing, China-a 10-year continuous single-center study. BMC Oral Health. 2020; 20(1):208. PMC: 7367409. DOI: 10.1186/s12903-020-01192-6. View

17.

Anwar N, Pervez S, Chundriger Q, Awan S, Moatter T, Ali T . Oral cancer: Clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan. PLoS One. 2020; 15(8):e0236359. PMC: 7410283. DOI: 10.1371/journal.pone.0236359. View

18.

Fitzmaurice C, Akinyemiju T, Al Lami F, Alam T, Alizadeh-Navaei R, Allen C . Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2018; 4(11):1553-1568. PMC: 6248091. DOI: 10.1001/jamaoncol.2018.2706. View

19.

Huang Y, Ho P, Jou Y, Wu C, Wang Y, Yang Y . Determining High Prevalence of Betel-Quid Chewing and Cigarette Smoking by Occupation Using the Taiwan National Health Interview Survey. Subst Use Misuse. 2020; 55(9):1472-1482. DOI: 10.1080/10826084.2020.1732421. View

20.

Fanaras N, Warnakulasuriya S . Oral Cancer Diagnosis in Primary Care. Prim Dent J. 2017; 5(1):64-68. DOI: 10.1177/205016841600500108. View