The Solution to Bicarbonate

Overview

Journal Am J Physiol Heart Circ Physiol

Publisher American Physiological Society

Specialties Cardiology & Vascular Diseases
Physiology

Date 2022 Mar 24

PMID 35324335

Authors

Ebbe Boedtkjer

Christian Aalkjaer

Affiliations

Soon will be listed here.

Citing Articles

Short-Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties.

Seefeldt J, Homilius C, Hansen J, Lassen T, Jespersen N, Jensen R J Am Heart Assoc. 2024; 13(9):e033744.

PMID: 38686853 PMC: 11179878. DOI: 10.1161/JAHA.123.033744.

Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate.

Gopalasingam N, Moeslund N, Christensen K, Berg-Hansen K, Seefeldt J, Homilius C J Am Heart Assoc. 2024; 13(8):e033628.

PMID: 38563382 PMC: 11262493. DOI: 10.1161/JAHA.123.033628.

Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer.

Axelsen T, Olesen C, Khan D, Mohammadi A, Bouzinova E, Nielsen C Br J Cancer. 2024; 130(7):1206-1220.

PMID: 38310186 PMC: 10991555. DOI: 10.1038/s41416-024-02591-0.

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility.

Homilius C, Seefeldt J, Axelsen J, Pedersen T, Sorensen T, Nielsen R Basic Res Cardiol. 2023; 118(1):37.

PMID: 37688627 PMC: 10492777. DOI: 10.1007/s00395-023-01008-y.

Myography of isolated blood vessels: Considerations for experimental design and combination with supplementary techniques.

Schubert R, Gaynullina D, Shvetsova A, Tarasova O Front Physiol. 2023; 14:1176748.

PMID: 37168231 PMC: 10165122. DOI: 10.3389/fphys.2023.1176748.

References

Turlapaty P, Altura B, Altura B . Interactions of Tris buffer and ethanol on agonist-induced responses of vascular smooth muscle and on calcium-45 uptake. J Pharmacol Exp Ther. 1979; 211(1):59-67. View

Thomsen A, Kim S, Aalbaek F, Aalkjaer C, Boedtkjer E . Intracellular acidification alters myogenic responsiveness and vasomotion of mouse middle cerebral arteries. J Cereb Blood Flow Metab. 2013; 34(1):161-8. PMC: 3887363. DOI: 10.1038/jcbfm.2013.192. View

Boedtkjer E . Acid-base regulation and sensing: Accelerators and brakes in metabolic regulation of cerebrovascular tone. J Cereb Blood Flow Metab. 2017; 38(4):588-602. PMC: 5888856. DOI: 10.1177/0271678X17733868. View

Boedtkjer E, Kim S, Aalkjaer C . Endothelial alkalinisation inhibits gap junction communication and endothelium-derived hyperpolarisations in mouse mesenteric arteries. J Physiol. 2013; 591(6):1447-61. PMC: 3607165. DOI: 10.1113/jphysiol.2012.247478. View

Hansen K, Staehr C, Rohde P, Homilius C, Kim S, Nyegaard M . is an ischemia risk locus essential for HCO-dependent regulation of endothelial function and tissue perfusion. Elife. 2020; 9. PMC: 7541084. DOI: 10.7554/eLife.57553. View

Bonde L, Boedtkjer E . Extracellular acidosis and very low [Na ] inhibit NBCn1- and NHE1-mediated net acid extrusion from mouse vascular smooth muscle cells. Acta Physiol (Oxf). 2017; 221(2):129-141. DOI: 10.1111/apha.12877. View

Rasmussen J, Boedtkjer E . Carbonic anhydrase inhibitors modify intracellular pH transients and contractions of rat middle cerebral arteries during CO/HCO fluctuations. J Cereb Blood Flow Metab. 2017; 38(3):492-505. PMC: 5851140. DOI: 10.1177/0271678X17699224. View

Wenceslau C, McCarthy C, Earley S, England S, Filosa J, Goulopoulou S . Guidelines for the measurement of vascular function and structure in isolated arteries and veins. Am J Physiol Heart Circ Physiol. 2021; 321(1):H77-H111. PMC: 8321813. DOI: 10.1152/ajpheart.01021.2020. View

Schmitz B, Nedele J, Guske K, Maase M, Lenders M, Schelleckes M . Soluble adenylyl cyclase in vascular endothelium: gene expression control of epithelial sodium channel-α, Na+/K+-ATPase-α/β, and mineralocorticoid receptor. Hypertension. 2014; 63(4):753-61. DOI: 10.1161/HYPERTENSIONAHA.113.02061. View

10.

Aalkjaer C, Hughes A . Chloride and bicarbonate transport in rat resistance arteries. J Physiol. 1991; 436:57-73. PMC: 1181494. DOI: 10.1113/jphysiol.1991.sp018539. View

11.

Boedtkjer E, Bentzon J, Dam V, Aalkjaer C . Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling. Cardiovasc Res. 2016; 111(3):227-39. DOI: 10.1093/cvr/cvw079. View

12.

Boedtkjer E, Hansen K, Boedtkjer D, Aalkjaer C, Boron W . Extracellular HCO3- is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ. J Cereb Blood Flow Metab. 2015; 36(5):965-80. PMC: 4853837. DOI: 10.1177/0271678X15610787. View

13.

Roos A, Boron W . Intracellular pH. Physiol Rev. 1981; 61(2):296-434. DOI: 10.1152/physrev.1981.61.2.296. View

14.

Zhao J, Hogan E, Bevensee M, Boron W . Out-of-equilibrium CO2/HCO3- solutions and their use in characterizing a new K/HCO3 cotransporter. Nature. 1995; 374(6523):636-9. DOI: 10.1038/374636a0. View

15.

Boedtkjer E, Praetorius J, Matchkov V, Stankevicius E, Mogensen S, Fuchtbauer A . Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice. Circulation. 2011; 124(17):1819-29. DOI: 10.1161/CIRCULATIONAHA.110.015974. View

16.

Boedtkjer E, Praetorius J, Aalkjaer C . NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells. Circ Res. 2006; 98(4):515-23. DOI: 10.1161/01.RES.0000204750.04971.76. View