The Comparison of Advanced Electrospun Materials Based on Poly(-3-hydroxybutyrate) with Natural and Synthetic Additives

Overview

Journal J Funct Biomater

Specialty Biomedical Engineering

Date 2022 Mar 24

PMID 35323223

Authors

Polina Tyubaeva

Ivetta Varyan

Alexey Krivandin

Olga Shatalova

Svetlana Karpova

Anton Lobanov

Anatoly Olkhov

Anatoly Popov

Affiliations

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Abstract

The comparison of the effect of porphyrins of natural and synthetic origin containing the same metal atom on the structure and properties of the semi-crystalline polymer matrix is of current concern. A large number of modifying additives and biodegradable polymers for biomedical purposes, composed of poly(-3-hydroxybutyrate)-porphyrin, are of particular interest because of the combination of their unique properties. The objective of this work are electrospun fibrous material based on poly(-3-hydroxybutyrate) (PHB), hemin (Hmi), and tetraphenylporphyrin with iron (Fe(TPP)Cl). The structure of these new materials was investigated by methods such as optical and scanning electron microscopy, X-ray diffraction analysis, Electron paramagnetic resonance method, and Differential scanning calorimetry. The properties of the electrospun materials were analyzed by mechanical and biological tests, and the wetting contact angle was measured. In this work, it was found that even small concentrations of porphyrin can increase the antimicrobial properties by 12 times, improve the physical and mechanical properties by at least 3.5 times, and vary hydrophobicity by at least 5%. At the same time, additives similar in the structure had an oppositely directed effect on the supramolecular structure, the composition of the crystalline, and the amorphous phases. The article considers assumptions about the nature of such differences due to the influence of Hmi and Fe(TPP)Cl) on the macromolecular and fibrous structure of PHB.

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References

Zozulia O, Korendovych I . Semi-Rationally Designed Short Peptides Self-Assemble and Bind Hemin to Promote Cyclopropanation. Angew Chem Int Ed Engl. 2020; 59(21):8108-8112. PMC: 7274867. DOI: 10.1002/anie.201916712. View

Dong L, Zang J, Wang W, Liu X, Zhang Y, Su J . Electrospun single iron atoms dispersed carbon nanofibers as high performance electrocatalysts toward oxygen reduction reaction in acid and alkaline media. J Colloid Interface Sci. 2020; 564:134-142. DOI: 10.1016/j.jcis.2019.12.120. View

Pegis M, Martin D, Wise C, Brezny A, Johnson S, Johnson L . Mechanism of Catalytic O Reduction by Iron Tetraphenylporphyrin. J Am Chem Soc. 2019; 141(20):8315-8326. PMC: 6684231. DOI: 10.1021/jacs.9b02640. View

Hsu C, Serio A, Amdursky N, Besnard C, Stevens M . Fabrication of Hemin-Doped Serum Albumin-Based Fibrous Scaffolds for Neural Tissue Engineering Applications. ACS Appl Mater Interfaces. 2018; 10(6):5305-5317. PMC: 5814958. DOI: 10.1021/acsami.7b18179. View

Suo Z, Chen J, Hou X, Hu Z, Xing F, Feng L . Growing prospects of DNA nanomaterials in novel biomedical applications. RSC Adv. 2022; 9(29):16479-16491. PMC: 9064466. DOI: 10.1039/c9ra01261c. View

Saad B, Neuenschwander P, Uhlschmid G, Suter U . New versatile, elastomeric, degradable polymeric materials for medicine. Int J Biol Macromol. 1999; 25(1-3):293-301. DOI: 10.1016/s0141-8130(99)00044-6. View

Lu Y, Berry S, Pfister T . Engineering novel metalloproteins: design of metal-binding sites into native protein scaffolds. Chem Rev. 2001; 101(10):3047-80. DOI: 10.1021/cr0000574. View

Alsharabasy A, Pandit A, Farras P . Recent Advances in the Design and Sensing Applications of Hemin/Coordination Polymer-Based Nanocomposites. Adv Mater. 2020; 33(2):e2003883. DOI: 10.1002/adma.202003883. View

Waghorn P . Radiolabelled porphyrins in nuclear medicine. J Labelled Comp Radiopharm. 2013; 57(4):304-9. DOI: 10.1002/jlcr.3166. View

10.

Cornibert J, Marchessault R . Physical properties of poly- -hydroxybutyrate. IV. Conformational analysis and crystalline structure. J Mol Biol. 1972; 71(3):735-56. DOI: 10.1016/s0022-2836(72)80035-4. View

11.

Joung Y, Bae J, Park K . Controlled release of heparin-binding growth factors using heparin-containing particulate systems for tissue regeneration. Expert Opin Drug Deliv. 2008; 5(11):1173-84. DOI: 10.1517/17425240802431811. View

12.

Tyubaeva P, Varyan I, Lobanov A, Olkhov A, Popov A . Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate). Polymers (Basel). 2021; 13(22). PMC: 8622405. DOI: 10.3390/polym13224024. View

13.

Imran M, Ramzan M, Qureshi A, Khan M, Tariq M . Emerging Applications of Porphyrins and Metalloporphyrins in Biomedicine and Diagnostic Magnetic Resonance Imaging. Biosensors (Basel). 2018; 8(4). PMC: 6316340. DOI: 10.3390/bios8040095. View

14.

Munj H, Nelson M, Karandikar P, Lannutti J, Tomasko D . Biocompatible electrospun polymer blends for biomedical applications. J Biomed Mater Res B Appl Biomater. 2014; 102(7):1517-27. DOI: 10.1002/jbm.b.33132. View

15.

Sun Z, She Y, Zhou Y, Song X, Li K . Synthesis, characterization and spectral properties of substituted tetraphenylporphyrin iron chloride complexes. Molecules. 2011; 16(4):2960-70. PMC: 6260636. DOI: 10.3390/molecules16042960. View

16.

Vieyra H, Juarez E, Lopez U, Morales A, Torres M . Cytotoxicity and biocompatibility of biomaterials based in polyhydroxybutyrate reinforced with cellulose nanowhiskers determined in human peripheral leukocytes. Biomed Mater. 2018; 13(4):045011. DOI: 10.1088/1748-605X/aaaaf4. View

17.

Wu J, Li S, Wei H . Integrated nanozymes: facile preparation and biomedical applications. Chem Commun (Camb). 2018; 54(50):6520-6530. DOI: 10.1039/C8CC01202D. View

18.

Williams S, Martin D, Horowitz D, Peoples O . PHA applications: addressing the price performance issue: I. Tissue engineering. Int J Biol Macromol. 1999; 25(1-3):111-21. DOI: 10.1016/s0141-8130(99)00022-7. View

19.

Pramual S, Assavanig A, Bergkvist M, Batt C, Sunintaboon P, Lirdprapamongkol K . Development and characterization of bio-derived polyhydroxyalkanoate nanoparticles as a delivery system for hydrophobic photodynamic therapy agents. J Mater Sci Mater Med. 2015; 27(2):40. DOI: 10.1007/s10856-015-5655-4. View

20.

Altaee N, El-Hiti G, Fahdil A, Sudesh K, Yousif E . Biodegradation of different formulations of polyhydroxybutyrate films in soil. Springerplus. 2016; 5(1):762. PMC: 4912537. DOI: 10.1186/s40064-016-2480-2. View