Insights Into Mitochondrial Dynamics in Chlamydial Infection

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2022 Mar 24

PMID 35321312

Authors

Yewei Yang

Wenbo Lei

Lanhua Zhao

Yating Wen

Zhongyu Li

Affiliations

Soon will be listed here.

Abstract

Mitochondria are intracellular organelles that are instrumental in the creation of energy, metabolism, apoptosis, and intrinsic immunity. Mitochondria exhibit an extraordinarily high degree of flexibility, and are constantly undergoing dynamic fusion and fission changes. is an intracellular bacterium that causes serious health problems in both humans and animals. Due to a deficiency of multiple metabolic enzymes, these pathogenic bacteria are highly dependent on their eukaryotic host cells, resulting in a close link between infection and host cell mitochondria. Indeed, increase mitochondrial fusion by inhibiting the activation of dynein-related protein 1 (DRP1), which can regulate host cell metabolism for extra energy. Additionally, can inhibit mitochondrial fission by blocking DRP1 oligomerization, preventing host cell apoptosis. These mechanisms are critical for maintaining a favorable environment for reproduction and growth of . This review discusses the molecular mechanisms of mitochondrial fusion and fission, as well as the mechanisms by which infection alters the mitochondrial dynamics and the prospects of limiting chlamydial development by altering mitochondrial dynamics.

Citing Articles

Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites.

Pan X, Hao E, Zhang F, Wei W, Du Z, Yan G Front Pharmacol. 2024; 15:1401961.

PMID: 39045049 PMC: 11263127. DOI: 10.3389/fphar.2024.1401961.

Amoebae as training grounds for microbial pathogens.

Price C, Hanford H, Al-Quadan T, Santic M, Shin C, Daas M mBio. 2024; 15(8):e0082724.

PMID: 38975782 PMC: 11323580. DOI: 10.1128/mbio.00827-24.

Infection Remodels Host Cell Mitochondria to Alter Energy Metabolism and Subvert Apoptosis.

Cheong H, Sulaiman S, Looi C, Chang L, Wong W Microorganisms. 2023; 11(6).

PMID: 37374883 PMC: 10301204. DOI: 10.3390/microorganisms11061382.

Modified Linggui Zhugan Decoction protects against ventricular remodeling through ameliorating mitochondrial damage in post-myocardial infarction rats.

Xiang M, Zhao X, Lu Y, Zhang Y, Ding F, Lv L Front Cardiovasc Med. 2023; 9:1038523.

PMID: 36704451 PMC: 9872118. DOI: 10.3389/fcvm.2022.1038523.

Chlamydia trachomatis Alters Mitochondrial Protein Composition and Secretes Effector Proteins That Target Mitochondria.

Dimond Z, Bauler L, Zhang Y, Carmody A, Hackstadt T mSphere. 2022; 7(6):e0042322.

PMID: 36286535 PMC: 9769516. DOI: 10.1128/msphere.00423-22.

References

Arribat Y, Broskey N, Greggio C, Boutant M, Conde Alonso S, Kulkarni S . Distinct patterns of skeletal muscle mitochondria fusion, fission and mitophagy upon duration of exercise training. Acta Physiol (Oxf). 2018; 225(2):e13179. DOI: 10.1111/apha.13179. View

Bota D, Davies K . Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol. 2002; 4(9):674-80. DOI: 10.1038/ncb836. View

Bustillo-Zabalbeitia I, Montessuit S, Raemy E, Basanez G, Terrones O, Martinou J . Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1. PLoS One. 2014; 9(7):e102738. PMC: 4103857. DOI: 10.1371/journal.pone.0102738. View

Frezza C, Cipolat S, Martins de Brito O, Micaroni M, Beznoussenko G, Rudka T . OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell. 2006; 126(1):177-89. DOI: 10.1016/j.cell.2006.06.025. View

Jheng H, Huang S, Kuo H, Hughes M, Tsai Y . Molecular insight and pharmacological approaches targeting mitochondrial dynamics in skeletal muscle during obesity. Ann N Y Acad Sci. 2015; 1350:82-94. DOI: 10.1111/nyas.12863. View

Wang X, Hybiske K, Stephens R . Orchestration of the mammalian host cell glucose transporter proteins-1 and 3 by Chlamydia contributes to intracellular growth and infectivity. Pathog Dis. 2017; 75(8). PMC: 6433302. DOI: 10.1093/femspd/ftx108. View

Liu R, Chan D . The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1. Mol Biol Cell. 2015; 26(24):4466-77. PMC: 4666140. DOI: 10.1091/mbc.E15-08-0591. View

Yu C, Zhao J, Yan L, Qi Y, Guo X, Lou Z . Structural insights into G domain dimerization and pathogenic mutation of OPA1. J Cell Biol. 2020; 219(7). PMC: 7337494. DOI: 10.1083/jcb.201907098. View

Frank S, Gaume B, Bergmann-Leitner E, Leitner W, Robert E, Catez F . The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell. 2001; 1(4):515-25. DOI: 10.1016/s1534-5807(01)00055-7. View

10.

Qi Y, Yan L, Yu C, Guo X, Zhou X, Hu X . Structures of human mitofusin 1 provide insight into mitochondrial tethering. J Cell Biol. 2016; 215(5):621-629. PMC: 5147005. DOI: 10.1083/jcb.201609019. View

11.

Manor U, Bartholomew S, Golani G, Christenson E, Kozlov M, Higgs H . A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. Elife. 2015; 4. PMC: 4574297. DOI: 10.7554/eLife.08828. View

12.

Twig G, Elorza A, Molina A, Mohamed H, Wikstrom J, Walzer G . Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008; 27(2):433-46. PMC: 2234339. DOI: 10.1038/sj.emboj.7601963. View

13.

Cao Y, Meng S, Chen Y, Feng J, Gu D, Yu B . MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. Nature. 2017; 542(7641):372-376. PMC: 5319402. DOI: 10.1038/nature21077. View

14.

Song Z, Chen H, Fiket M, Alexander C, Chan D . OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L. J Cell Biol. 2007; 178(5):749-55. PMC: 2064540. DOI: 10.1083/jcb.200704110. View

15.

Abdul-Sater A, Said-Sadier N, Lam V, Singh B, Pettengill M, Soares F . Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1. J Biol Chem. 2010; 285(53):41637-45. PMC: 3009891. DOI: 10.1074/jbc.M110.137885. View

16.

Kim B, Kim J, Yoon Y, Santiago M, Brown M, Park J . Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation. Am J Physiol Regul Integr Comp Physiol. 2013; 305(8):R927-38. DOI: 10.1152/ajpregu.00502.2012. View

17.

Kerr M, Gomez G, Ferguson C, Tanzer M, Murphy J, Yap A . Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis. Nat Commun. 2017; 8:14729. PMC: 5353685. DOI: 10.1038/ncomms14729. View

18.

Anis E, Zafeer M, Firdaus F, Islam S, Khan A, Ali A . Ferulic acid reinstates mitochondrial dynamics through PGC1α expression modulation in 6-hydroxydopamine lesioned rats. Phytother Res. 2019; 34(1):214-226. DOI: 10.1002/ptr.6523. View

19.

Chen H, Detmer S, Ewald A, Griffin E, Fraser S, Chan D . Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol. 2003; 160(2):189-200. PMC: 2172648. DOI: 10.1083/jcb.200211046. View

20.

Li P, Nijhawan D, Budihardjo I, Srinivasula S, Ahmad M, Alnemri E . Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997; 91(4):479-89. DOI: 10.1016/s0092-8674(00)80434-1. View