Headache As a Neurologic Manifestation of Systemic Disease

Overview

Journal Curr Treat Options Neurol

Specialty Neurology

Date 2022 Mar 23

PMID 35317303

Authors

Alexandra N Cocores

Teshamae S Monteith

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: This is an update of headache attributed to systemic disease and current therapeutic strategies. Clinical scenarios are discussed.

Recent Findings: The diagnosis of headache attributed to metabolic or systemic disorder appears in the Appendix of International Classification of Headache Disorders, Third Edition, and requires further evaluation and validation. However, recent studies characterizing headache appear in the literature. Specific treatment includes addressing underlying systemic disorders, managing concurrent primary headache, and treating comorbidities that may exacerbate headache. Evidence for specific treatment trials for headache as a symptom is lacking, including headaches post-COVID19 infection. Calcitonin gene-related peptide receptor antagonists and 5-HT receptor agonists are attractive options for migraine with vascular comorbidities, but long-term studies are needed.

Summary: Headache is commonly encountered as a manifestation or complication of systemic disease. Further research is needed to validate headache associated with systemic disorders and to determine optimal treatment strategies.

Citing Articles

Severe Headache in Primary Sjögren's Syndrome Responded to Rituximab.

Kudsi M, Haidar G, Hadid B, Roumieh E, Al-Sayed S Eur J Case Rep Intern Med. 2023; 10(10):004051.

PMID: 37789982 PMC: 10545156. DOI: 10.12890/2023_004051.

Contrasting Hygiene-Related Gastrointestinal Infections and Stress-Related Diseases at a Primary Health Care Facility within a Sub-Saharan African City: Before and during the COVID-19 Pandemic.

Tetteh-Quarcoo P, Afutu E, Wiafe-Ansong M, Kotey F, Dayie N, Donkor E Diseases. 2023; 11(1).

PMID: 36648867 PMC: 9844452. DOI: 10.3390/diseases11010002.

References

Sheikh H, Cho T . Clinical aspects of headache in HIV. Headache. 2014; 54(5):939-45. DOI: 10.1111/head.12357. View

Mokri B, Maher C, Sencakova D . Spontaneous CSF leaks: underlying disorder of connective tissue. Neurology. 2002; 58(5):814-6. DOI: 10.1212/wnl.58.5.814. View

Kristiansen H, Kvaerner K, Akre H, Overland B, Sandvik L, Russell M . Sleep apnoea headache in the general population. Cephalalgia. 2011; 32(6):451-8. DOI: 10.1177/0333102411431900. View

Aamodt A, Stovner L, Hagen K, Zwart J . Comorbidity of headache and gastrointestinal complaints. The Head-HUNT Study. Cephalalgia. 2008; 28(2):144-51. DOI: 10.1111/j.1468-2982.2007.01486.x. View

Yamani N, Olesen J . New daily persistent headache: a systematic review on an enigmatic disorder. J Headache Pain. 2019; 20(1):80. PMC: 6734284. DOI: 10.1186/s10194-019-1022-z. View

Rozen T . Daily persistent headache after a viral illness during a worldwide pandemic may not be a new occurrence: Lessons from the 1890 Russian/Asiatic flu. Cephalalgia. 2020; 40(13):1406-1409. PMC: 7645599. DOI: 10.1177/0333102420965132. View

. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1):1-211. DOI: 10.1177/0333102417738202. View

Murphy M, Szabados E, Mitty J . Lyme disease associated with postganglionic Horner syndrome and Raeder paratrigeminal neuralgia. J Neuroophthalmol. 2007; 27(2):123-4. DOI: 10.1097/WNO.0b013e318064e4ba. View

Immink R, van den Born B, van Montfrans G, Koopmans R, Karemaker J, Van Lieshout J . Impaired cerebral autoregulation in patients with malignant hypertension. Circulation. 2004; 110(15):2241-5. DOI: 10.1161/01.CIR.0000144472.08647.40. View

10.

Kristiansen H, Kvaerner K, Akre H, Overland B, Russell M . Migraine and sleep apnea in the general population. J Headache Pain. 2010; 12(1):55-61. PMC: 3056010. DOI: 10.1007/s10194-010-0268-2. View

11.

Budhram A, Le C, Jenkins M . Lyme Disease Presenting With Raeder Syndrome. Headache. 2017; 58(2):317-318. DOI: 10.1111/head.13220. View

12.

Hanly J, Urowitz M, OKeeffe A, Gordon C, Bae S, Sanchez-Guerrero J . Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study. Arthritis Rheum. 2013; 65(11):2887-97. DOI: 10.1002/art.38106. View

13.

Goksan B, Gunduz A, Karadeniz D, Agan K, Tascilar F, Tan F . Morning headache in sleep apnoea: clinical and polysomnographic evaluation and response to nasal continuous positive airway pressure. Cephalalgia. 2009; 29(6):635-41. DOI: 10.1111/j.1468-2982.2008.01781.x. View

14.

Robbins M, Farmakidis C, Dayal A, Lipton R . Acute headache diagnosis in pregnant women: a hospital-based study. Neurology. 2015; 85(12):1024-30. PMC: 4603601. DOI: 10.1212/WNL.0000000000001954. View

15.

Sperling J, D Dahlke J, Huber W, Sibai B . The Role of Headache in the Classification and Management of Hypertensive Disorders in Pregnancy. Obstet Gynecol. 2015; 126(2):297-302. DOI: 10.1097/AOG.0000000000000966. View

16.

Angus P . Don't forget phaeochromocytoma in the differential diagnosis of thunderclap headache. BMJ. 2013; 346:f682. DOI: 10.1136/bmj.f682. View

17.

Scelsa S, Lipton R, Sander H, Herskovitz S . Headache characteristics in hospitalized patients with Lyme disease. Headache. 1995; 35(3):125-30. DOI: 10.1111/j.1526-4610.1995.hed3503125.x. View

18.

Solomon S, Cappa K . The headache of temporal arteritis. J Am Geriatr Soc. 1987; 35(2):163-5. DOI: 10.1111/j.1532-5415.1987.tb01348.x. View

19.

Singh N, Sahota P . Sleep-related headache and its management. Curr Treat Options Neurol. 2013; 15(6):704-22. DOI: 10.1007/s11940-013-0258-1. View

20.

Vilela-Martin J, Vaz-de-Melo R, Kuniyoshi C, Abdo A, Yugar-Toledo J . Hypertensive crisis: clinical-epidemiological profile. Hypertens Res. 2010; 34(3):367-71. DOI: 10.1038/hr.2010.245. View