Neuroinflammation and Neuropathology

Overview

Journal Neurosci Behav Physiol

Publisher Springer

Date 2022 Mar 23

PMID 35317271

Authors

R G Esin

D R Safina

A R Khakimova

O R Esin

Affiliations

Soon will be listed here.

Abstract

This review addresses the current understanding of the role of autoimmune neuroinflammation in the pathogenesis of vascular, neurodegenerative, and other diseases of the nervous system. The mechanisms of responses of resident CNS cells (glial cells, astrocytes) and peripheral immune system cells are presented. The therapeutic potentials of phosphodiesterase inhibitors, which have antiaggregant properties and can suppress autoimmune inflammation, are discussed. The phosphodiesterase inhibitor dipyridamole is regarded as a potential drug for this purpose.

Citing Articles

Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived Microglia.

Garg A, Vo S, Brase L, Aladyeva E, Albanus R, Nallapu A Res Sq. 2024; .

PMID: 39483903 PMC: 11527241. DOI: 10.21203/rs.3.rs-5045715/v1.

The Impact of Dipyridamole on Disease-Associated Microglia Phenotypic Transformation in White Matter Lesions Induced by Chronic Cerebral Hypoperfusion.

Cheng W, Wang Y, Zhang L, Cheng C, Chen X, Huang W Neurochem Res. 2023; 49(3):744-757.

PMID: 38102341 DOI: 10.1007/s11064-023-04066-9.

First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.

Mahmood S, Lozano Gonzalez M, Tummalapalli S, Eberhard J, Ly J, Hoffman C J Med Chem. 2023; 66(21):14597-14608.

PMID: 37862143 PMC: 10641827. DOI: 10.1021/acs.jmedchem.3c01088.

Reversal of spatial memory impairment by phosphodiesterase 3 inhibitor cilostazol is associated with reduced neuroinflammation and increased cerebral glucose uptake in aged male mice.

Yanai S, Tago T, Toyohara J, Arasaki T, Endo S Front Pharmacol. 2023; 13:1031637.

PMID: 36618932 PMC: 9810637. DOI: 10.3389/fphar.2022.1031637.

References

Jayaraj R, Azimullah S, Beiram R, Jalal F, Rosenberg G . Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019; 16(1):142. PMC: 6617684. DOI: 10.1186/s12974-019-1516-2. View

Nachman R, Rafii S . Platelets, petechiae, and preservation of the vascular wall. N Engl J Med. 2008; 359(12):1261-70. PMC: 2935201. DOI: 10.1056/NEJMra0800887. View

Suidan G, Brill A, De Meyer S, Voorhees J, Cifuni S, Cabral J . Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice. Arterioscler Thromb Vasc Biol. 2013; 33(9):2112-20. PMC: 3854012. DOI: 10.1161/ATVBAHA.113.301362. View

DiSabato D, Quan N, Godbout J . Neuroinflammation: the devil is in the details. J Neurochem. 2016; 139 Suppl 2:136-153. PMC: 5025335. DOI: 10.1111/jnc.13607. View

Chakrabarti S, Freedman J . Dipyridamole, cerebrovascular disease, and the vasculature. Vascul Pharmacol. 2008; 48(4-6):143-9. DOI: 10.1016/j.vph.2007.12.004. View

Murr C, Widner B, Wirleitner B, Fuchs D . Neopterin as a marker for immune system activation. Curr Drug Metab. 2002; 3(2):175-87. DOI: 10.2174/1389200024605082. View

Fagiolo U, Cossarizza A, Scala E, Fanales-Belasio E, Ortolani C, Cozzi E . Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol. 1993; 23(9):2375-8. DOI: 10.1002/eji.1830230950. View

Ciacciarelli M, Zerbinati C, Violi F, Iuliano L . Dipyridamole: a drug with unrecognized antioxidant activity. Curr Top Med Chem. 2015; 15(9):822-9. DOI: 10.2174/1568026615666150220111942. View

Fagiolo U, Cossarizza A, Santacaterina S, Ortolani C, Monti D, Paganelli R . Increased cytokine production by peripheral blood mononuclear cells from healthy elderly people. Ann N Y Acad Sci. 1992; 663:490-3. DOI: 10.1111/j.1749-6632.1992.tb38712.x. View

10.

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T . Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015; 18(11):1584-93. PMC: 4694577. DOI: 10.1038/nn.4132. View

11.

Weyrich A, Denis M, Kuhlmann-Eyre J, Spencer E, Dixon D, Marathe G . Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates. Circulation. 2005; 111(5):633-42. DOI: 10.1161/01.CIR.0000154607.90506.45. View

12.

Rempe R, Hartz A, Bauer B . Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers. J Cereb Blood Flow Metab. 2016; 36(9):1481-507. PMC: 5012524. DOI: 10.1177/0271678X16655551. View

13.

Watcharotayangul J, Mao L, Xu H, Vetri F, Baughman V, Paisansathan C . Post-ischemic vascular adhesion protein-1 inhibition provides neuroprotection in a rat temporary middle cerebral artery occlusion model. J Neurochem. 2012; 123 Suppl 2:116-24. PMC: 3481219. DOI: 10.1111/j.1471-4159.2012.07950.x. View

14.

Iadecola C, Anrather J . The immunology of stroke: from mechanisms to translation. Nat Med. 2011; 17(7):796-808. PMC: 3137275. DOI: 10.1038/nm.2399. View

15.

Guo S, Stins M, Ning M, Lo E . Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells. Cerebrovasc Dis. 2010; 30(3):290-6. PMC: 3214842. DOI: 10.1159/000319072. View

16.

Li M, Li Z, Yao Y, Jin W, Wood K, Liu Q . Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. Proc Natl Acad Sci U S A. 2016; 114(3):E396-E405. PMC: 5255606. DOI: 10.1073/pnas.1612930114. View

17.

Tanaka R, Komine-Kobayashi M, Mochizuki H, Yamada M, Furuya T, Migita M . Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia. Neuroscience. 2003; 117(3):531-9. DOI: 10.1016/s0306-4522(02)00954-5. View

18.

Wardlaw J, Doubal F, Armitage P, Chappell F, Carpenter T, Munoz Maniega S . Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. Ann Neurol. 2009; 65(2):194-202. DOI: 10.1002/ana.21549. View

19.

Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S . Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 2009; 15(2):192-9. DOI: 10.1038/nm.1927. View

20.

Yilmaz G, Arumugam T, Stokes K, Granger D . Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation. 2006; 113(17):2105-12. DOI: 10.1161/CIRCULATIONAHA.105.593046. View