Impact of Personal, Subhourly Exposure to Ultrafine Particles on Respiratory Health in Adolescents with Asthma

Overview

Journal Ann Am Thorac Soc

Specialty Pulmonary Medicine

Date 2022 Mar 22

PMID 35315743

Authors

Ashley L Turner

Cole Brokamp

Chris Wolfe

Tiina Reponen

Patrick H Ryan

Affiliations

Soon will be listed here.

Abstract

Ultrafine particle (UFP; particles <0.1 μm in diameter) concentrations exhibit high spatiotemporal variability; thus, individual-level exposures and health risks are difficult to estimate. To determine the effects of recent UFP exposures on respiratory health outcomes in children and to determine if children with asthma are at increased risk. Personal sampling of UFPs was completed by adolescents in combination with repeated personal spirometry measurements and ecological momentary assessment of respiratory symptoms (wheeze, cough, and/or shortness of breath). We assessed the association between UFP exposures every 30 minutes up to 150 minutes before measuring forced expiratory volume in 1 second (FEV), peak expiratory flow, and respiratory symptoms using mixed-effects models and interaction with asthma diagnosis. Participants ( = 105; 43% with asthma) completed an average of 11 spirometry measurements and 16 symptom responses throughout sampling. After adjustments (maternal education, physical activity, season, and distance to nearest roadway), a 10-fold increase in UFP exposure was significantly associated with a 0.04-L decrease (95% confidence interval [CI], -0.07 to -0.001) in FEV 90 minutes later. Asthma status modified this association in which participants with asthma had significantly lower FEV values in response to UFP exposures 30 minutes earlier than participants without asthma. We found a significant increase in the odds of reporting a respiratory symptom 30 minutes after increased UFP exposure (odds ratio, 1.8; 95% CI, 1.00 to 3.00). Greater UFP exposure conferred deleterious effects on lung function and respiratory symptoms within 90 minutes of exposure and was more pronounced among participants with asthma.

Citing Articles

Integrating Real-Time Air Quality Monitoring, Ecological Momentary Assessment, and Spirometry to Evaluate Asthma Symptoms: Usability Study.

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Ryan P, Wolfe C, Parsons A, Brokamp C, Turner A, Haynes E J Clin Transl Sci. 2023; 7(1):e76.

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References

Hegewald M, Lefor M, Jensen R, Crapo R, Kritchevsky S, Haggerty C . Peak expiratory flow is not a quality indicator for spirometry: peak expiratory flow variability and FEV1 are poorly correlated in an elderly population. Chest. 2007; 131(5):1494-9. DOI: 10.1378/chest.06-2707. View

Medarov B, Pavlov V, Rossoff L . Diurnal variations in human pulmonary function. Int J Clin Exp Med. 2008; 1(3):267-73. PMC: 2592592. View

Buonanno G, Marks G, Morawska L . Health effects of daily airborne particle dose in children: direct association between personal dose and respiratory health effects. Environ Pollut. 2013; 180:246-50. DOI: 10.1016/j.envpol.2013.05.039. View

Desai U, Watson A . Associations Between Ultrafine Particles and Co-Pollutant Concentrations in the Tampa Bay Area. J Environ Health. 2016; 78(9):14-21. View

Park H, Gilbreath S, Barakatt E . Respiratory outcomes of ultrafine particulate matter (UFPM) as a surrogate measure of near-roadway exposures among bicyclists. Environ Health. 2017; 16(1):6. PMC: 5299642. DOI: 10.1186/s12940-017-0212-x. View

Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J . Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006; 114(8):1172-8. PMC: 1552007. DOI: 10.1289/ehp.9030. View

Olvera H, Perez D, Clague J, Cheng Y, Li W, Amaya M . The effect of ventilation, age, and asthmatic condition on ultrafine particle deposition in children. Pulm Med. 2012; 2012:736290. PMC: 3401531. DOI: 10.1155/2012/736290. View

Newcomb P, Hunt A, Rast P, Cauble D, Rowe N, Li J . Acute effects of walking environment and GSTM1 variants in children with asthma. Biol Res Nurs. 2011; 14(1):55-64. DOI: 10.1177/1099800410389167. View

Andersen Z, Loft S, Ketzel M, Stage M, Scheike T, Hermansen M . Ambient air pollution triggers wheezing symptoms in infants. Thorax. 2008; 63(8):710-6. DOI: 10.1136/thx.2007.085480. View

10.

Leikauf G, Kim S, Jang A . Mechanisms of ultrafine particle-induced respiratory health effects. Exp Mol Med. 2020; 52(3):329-337. PMC: 7156674. DOI: 10.1038/s12276-020-0394-0. View

11.

Karottki D, Beko G, Clausen G, Madsen A, Andersen Z, Massling A . Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects. Environ Int. 2014; 73:372-81. DOI: 10.1016/j.envint.2014.08.019. View

12.

Li Y, Feng L, Chen B, Kim H, Yi S, Guo Y . Association of urban particle numbers and sources with lung function among children with asthma or allergies. Sci Total Environ. 2015; 542(Pt A):841-4. DOI: 10.1016/j.scitotenv.2015.10.098. View

13.

Peters A, Wichmann H, Tuch T, Heinrich J, Heyder J . Respiratory effects are associated with the number of ultrafine particles. Am J Respir Crit Care Med. 1997; 155(4):1376-83. DOI: 10.1164/ajrccm.155.4.9105082. View

14.

Aggarwal A, Gupta D, Jindal S . The relationship between FEV1 and peak expiratory flow in patients with airways obstruction is poor. Chest. 2006; 130(5):1454-61. DOI: 10.1378/chest.130.5.1454. View

15.

Kim J, Elfman L, Wieslander G, Ferm M, Toren K, Norback D . Respiratory health among Korean pupils in relation to home, school and outdoor environment. J Korean Med Sci. 2011; 26(2):166-73. PMC: 3030998. DOI: 10.3346/jkms.2011.26.2.166. View

16.

Ozkaynak H, Baxter L, Dionisio K, Burke J . Air pollution exposure prediction approaches used in air pollution epidemiology studies. J Expo Sci Environ Epidemiol. 2013; 23(6):566-72. DOI: 10.1038/jes.2013.15. View

17.

Gong Jr H, Linn W, Clark K, Anderson K, Sioutas C, Alexis N . Exposures of healthy and asthmatic volunteers to concentrated ambient ultrafine particles in Los Angeles. Inhal Toxicol. 2008; 20(6):533-45. DOI: 10.1080/08958370801911340. View

18.

Vriens A, Nawrot T, Saenen N, Provost E, Kicinski M, Lefebvre W . Recent exposure to ultrafine particles in school children alters miR-222 expression in the extracellular fraction of saliva. Environ Health. 2016; 15(1):80. PMC: 4962430. DOI: 10.1186/s12940-016-0162-8. View

19.

Evans K, Halterman J, Hopke P, Fagnano M, Rich D . Increased ultrafine particles and carbon monoxide concentrations are associated with asthma exacerbation among urban children. Environ Res. 2014; 129:11-9. PMC: 3947881. DOI: 10.1016/j.envres.2013.12.001. View

20.

Turner A, Brokamp C, Wolfe C, Reponen T, Ryan P . Personal exposure to average weekly ultrafine particles, lung function, and respiratory symptoms in asthmatic and non-asthmatic adolescents. Environ Int. 2021; 156:106740. PMC: 8380734. DOI: 10.1016/j.envint.2021.106740. View