False-positive Elevation of Beta-D-glucan and Aspergillus Galactomannan Levels Due to Mendelson's Syndrome After Rice Aspiration

Overview

Journal Intern Med

Specialty General Medicine

Date 2022 Mar 22

PMID 35314546

Authors

Tasuku Yamamoto

Keiji Oishi

Junki Suizu

Keita Murakawa

Yukari Hisamoto

Tetsuya Fujii

Misa Harada

Ayumi Chikumoto

Yujiro Kikuchi

Kazuki Hamada

Sho Uehara

Syuichiro Ohata

Yoriyuki Murata

Kenji Sakamoto

Yoshikazu Yamaji

Maki Asami-Noyama

Nobutaka Edakuni

Tomoyuki Kakugawa

Tsunahiko Hirano

Kazuto Matsunaga

Affiliations

Soon will be listed here.

Abstract

Both 1,3-beta-D-glucan (BDG) and galactomannan (GM) are polysaccharide components of the fungal cell wall. Although elevated levels of serum BDG and Aspergillus GM suggest invasive fungal infection or Pneumocystis pneumonia and aspergillosis, respectively, it is also necessary to consider the possibility of false-positives. We herein report a 68-year-old man with marked elevation in serum BDG and GM levels accompanied by Mendelson's syndrome after rice aspiration. With the improvement of Mendelson's syndrome, his serum BDG and GM levels decreased. The false-positive serum BDG and GM findings may have been due to his aspiration of food containing them. It is important to take a detailed history of aspiration in addition to making a conventional differential diagnosis in patients with pneumonia with elevated serum BDG and GM levels.

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