HuR Promotes the Progression of Gastric Cancer Through Mediating CDC5L Expression

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2022 Mar 22

PMID 35313568

Authors

Jing Cui

Nanjing Cao

Guochao Wang

Fuhua Wang

Bin Yang

Jian Wang

YongQiang Lv

Yunqing Chen

Feng Li

Affiliations

Soon will be listed here.

Abstract

Methods: We performed qRT-PCR, cell cycle assay, cell migration, and mouse transplantation model analysis in our experiments. It has been clarified that HuR and microRNAs (miRNAs) have important interplays in the regulation of tumor progression.

Results: This study found microRNA-133b (miR-133b), as a HuR-sponged miRNA in GC cells. Downregulation of HuR can promote the expression of miR-133b and further affect the downstream cyclin CDC5L. The expressions of miR-133b were slightly lower in GC tissues than adjacent normal tissues.

Conclusion: Our studies suggest that HuR and miR-133b are involved in the development and pathological process of GC cells.

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