Neuropeptide Y (NPY)-like Immunoreactivity in Peripheral and Central Nerve Fibres of the Golden Hamster (Mesocricetus Auratus) with Special Respect to Pineal Gland Innervation

Overview

Journal Histochemistry

Specialty Biochemistry

Date 1986 Jan 1

PMID 3531105

Citations 10

Authors

H Schroder

Affiliations

Soon will be listed here.

Abstract

Information on the ambient lighting conditions is conveyed from the retina to the pineal organ by a neuronal pathway involving the suprachiasmatic nucleus (SCN) which acts as a circadian pacemaker. In the hamster, circadian rhythms have been shown to be influenced by injection of neuropeptide Y (NPY) into the SCN. Since NPY-immunoreactive nerve fibres are present in the rat and guinea-pig pineal glands it appeared of interest to investigate the hamster pineal as part of the circadian rhythm generating/regulating system. For comparison kidney, small intestine and cerebral cortex were studied. Like in the other rodent species so far investigated only a few of the abundant sympathetic nerve fibres in the hamster pineal gland are NPY-immunoreactive, in contrast to the relatively rich innervation of the other organs. This speaks in favour of a possible central origin of pineal NPY-immunoreactive fibres. These may either exert vasoregulatory effects on pineal vasculature or be involved in the modulation of alpha-adrenergic receptor mediated regulation of pineal metabolism.

Citing Articles

Neuropeptide Y in the adult and fetal human pineal gland.

Moller M, Phansuwan-Pujito P, Badiu C Biomed Res Int. 2014; 2014:868567.

PMID: 24757681 PMC: 3976832. DOI: 10.1155/2014/868567.

Protein gene product (PGP) 9.5 immunoreactivity in nerve fibres and pinealocytes of guinea-pig pineal gland: interrelationship with tyrosine- hydroxylase- and neuropeptide-Y-immunoreactive nerve fibres.

Romeo H, Weihe E, Muller S, Vollrath L Cell Tissue Res. 1993; 271(3):477-84.

PMID: 8097136 DOI: 10.1007/BF02913730.

Innervation of the cat pineal gland by neuropeptide Y-immunoreactive nerve fibers: an experimental immunohistochemical study.

Moller M, Phansuwan-Pujito P, Pramaulkijja S, Kotchabhakdi N, Govitrapong P Cell Tissue Res. 1994; 276(3):545-50.

PMID: 8062343 DOI: 10.1007/BF00343951.

Noradrenergic innervation of the pineal gland--histochemical basis of scintigraphic imaging?.

Schroder H Neurosurg Rev. 1987; 10(1):57-60.

PMID: 3670629 DOI: 10.1007/BF01780596.

In vitro effect of neuropeptide Y on melatonin and norepinephrine release in rat pineal gland.

Vacas M, Sarmiento M, Pereyra E, Etchegoyen G, Cardinali D Cell Mol Neurobiol. 1987; 7(3):309-15.

PMID: 3440284 PMC: 11567382. DOI: 10.1007/BF00711307.

References

Lundberg J, Terenius L, Hokfelt T, Martling C, Tatemoto K, Mutt V . Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand. 1982; 116(4):477-80. DOI: 10.1111/j.1748-1716.1982.tb07171.x. View

Tatemoto K, Carlquist M, Mutt V . Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 1982; 296(5858):659-60. DOI: 10.1038/296659a0. View

Berk M, Finkelstein J . An autoradiographic determination of the efferent projections of the suprachiasmatic nucleus of the hypothalamus. Brain Res. 1981; 226(1-2):1-13. DOI: 10.1016/0006-8993(81)91079-9. View

Albers H, Ferris C . Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms. Neurosci Lett. 1984; 50(1-3):163-8. DOI: 10.1016/0304-3940(84)90480-4. View

Thomas J, Sakai K, Holck M, MARKS B . Dopamine-beta-hydroxylase: a modulator of beta adrenergic receptor activity. Res Commun Chem Pathol Pharmacol. 1980; 29(1):3-13. View

Torre J, Surgeon J . A methodological approach to rapid and sensitive monoamine histofluorescence using a modified glyoxylic acid technique: the SPG method. Histochemistry. 1976; 49(2):81-93. DOI: 10.1007/BF00495672. View

Card J, Moore R . The suprachiasmatic nucleus of the golden hamster: immunohistochemical analysis of cell and fiber distribution. Neuroscience. 1984; 13(2):415-31. DOI: 10.1016/0306-4522(84)90240-9. View

Bowers C, Dahm L, Zigmond R . The number and distribution of sympathetic neurons that innervate the rat pineal gland. Neuroscience. 1984; 13(1):87-96. DOI: 10.1016/0306-4522(84)90261-6. View

Schroder H, Vollrath L . Distribution of dopamine-beta-hydroxylase-like immunoreactivity in the rat pineal organ. Histochemistry. 1985; 83(4):375-80. DOI: 10.1007/BF00684385. View

10.

QUAY W . Twenty-four-hour rhythmicity in carbonic anhydrase activities of choroid plexuses and pineal gland. Anat Rec. 1972; 174(3):279-87. DOI: 10.1002/ar.1091740302. View

11.

Majane E, Alho H, Kataoka Y, Lee C, Yang H . Neuropeptide Y in bovine adrenal glands: distribution and characterization. Endocrinology. 1985; 117(3):1162-8. DOI: 10.1210/endo-117-3-1162. View

12.

Dahlof C, Dahlof P, Lundberg J . Neuropeptide Y (NPY): enhancement of blood pressure increase upon alpha-adrenoceptor activation and direct pressor effects in pithed rats. Eur J Pharmacol. 1985; 109(2):289-92. DOI: 10.1016/0014-2999(85)90433-9. View

13.

Bowers C, Zigmond R . Electrical stimulation of the cerivcal sympathetic trunks mimics the effects of darkness on the activity of serotonin:N-acetyltransferase in the rat pineal. Brain Res. 1980; 185(2):435-40. DOI: 10.1016/0006-8993(80)91082-3. View

14.

Ekblad E, Edvinsson L, Wahlestedt C, Uddman R, Hakanson R, Sundler F . Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regul Pept. 1984; 8(3):225-35. DOI: 10.1016/0167-0115(84)90064-8. View

15.

Lundberg J, Stjarne L . Neuropeptide Y (NPY) depresses the secretion of 3H-noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens. Acta Physiol Scand. 1984; 120(3):477-9. DOI: 10.1111/j.1748-1716.1984.tb07410.x. View

16.

Kappers J . The development, topographical relations and innervation of the epiphysis cerebri in the albino rat. Z Zellforsch Mikrosk Anat. 1960; 52:163-215. DOI: 10.1007/BF00338980. View

17.

Moore R, Klein D . Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity. Brain Res. 1974; 71(1):17-33. DOI: 10.1016/0006-8993(74)90188-7. View

18.

Luiten P, Ter Horst G, Karst H, Steffens A . The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Res. 1985; 329(1-2):374-8. DOI: 10.1016/0006-8993(85)90554-2. View

19.

Uddman R, Ekblad E, Edvinsson L, Hakanson R, Sundler F . Neuropeptide Y-like immunoreactivity in perivascular nerve fibres of the guinea-pig. Regul Pept. 1985; 10(2-3):243-57. DOI: 10.1016/0167-0115(85)90019-9. View

20.

Moore R, Gustafson E, Card J . Identical immunoreactivity of afferents to the rat suprachiasmatic nucleus with antisera against avian pancreatic polypeptide, molluscan cardioexcitatory peptide and neuropeptide Y. Cell Tissue Res. 1984; 236(1):41-6. DOI: 10.1007/BF00216511. View