Biomaterial Scaffolds for Clinical Procedures in Endodontic Regeneration

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2022 Mar 21

PMID 35310382

Authors

He Liu

Jing Lu

Qianzhou Jiang

Markus Haapasalo

Junrong Qian

Franklin R Tay

Ya Shen

Affiliations

Soon will be listed here.

Abstract

Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics. These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed to have poor prognosis. As a component biological triad of tissue engineering (i.e., stem cells, growth factors and scaffolds), biomaterial scaffolds have demonstrated clinical potential as an armamentarium in regenerative endodontic procedures and achieved remarkable advancements. The aim of the present review is to provide a broad overview of biomaterials employed for scaffolding in regenerative endodontics. The favorable properties and limitations of biomaterials organized in naturally derived, host-derived and synthetic material categories were discussed. Preclinical and clinical studies published over the past five years on the performance of biomaterial scaffolds, as well as current challenges and future perspectives for the application of biomaterials for scaffolding and clinical evaluation of biomaterial scaffolds in regenerative endodontic procedures were addressed in depth.

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