Tetrahedral Framework Nucleic Acids-based Delivery of MicroRNA-155 Inhibits Choroidal Neovascularization by Regulating the Polarization of Macrophages

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2022 Mar 21

PMID 35310341

Authors

Xin Qin

Lirong Xiao

Ni Li

Chen Hou

Wenman Li

Jiajie Li

Naihong Yan

Yunfeng Lin

Affiliations

Soon will be listed here.

Abstract

Choroidal neovascularization (CNV) is a common pathological feature of various eye diseases and an important cause of visual impairment in middle-aged and elderly patients. In previous studies, tetrahedral framework nucleic acids (tFNAs) showed good carrier performance. In this experiment, we developed microRNA-155-equipped tFNAs (T-155) and explored its biological effects on CNV. Based on the results of in-vitro experiments, T-155 could regulate macrophages into the antiangiogenic M1 type. Then, we injected T-155 into the vitreous of laser-induced CNV model mice and found that T-155 significantly reduced the size and area of CNV, inhibited blood vessel leakage. In summary, we prove that T-155 could regulate the inflammatory process of CNV by polarizing macrophages, thereby improving the symptoms of CNV. Thus, T-155 might become a new DNA-based drug with great potential for treating CNV.

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