Mapping Bacterial Diversity and Metabolic Functionality of the Human Respiratory Tract Microbiome

Overview

Journal J Oral Microbiol

Specialty Dentistry

Date 2022 Mar 21

PMID 35309410

Authors

Leonardo Mancabelli

Christian Milani

Federico Fontana

Gabriele Andrea Lugli

Chiara Tarracchini

Francesca Turroni

Douwe Van Sinderen

Marco Ventura

Affiliations

Soon will be listed here.

Abstract

Background: The Human Respiratory Tract (HRT) is colonized by various microbial taxa, known as HRT microbiota, in a manner that is indicative of mutualistic interaction between such microorganisms and their host.

Aim: To investigate the microbial composition of the HRT and its possible correlation with the different compartments of the respiratory tract.

Methods: In the current study, we performed an in-depth meta-analysis of 849 HRT samples from public shotgun metagenomic datasets obtained through several distinct collection methods.

Results: The statistical robustness provided by this meta-analysis allowed the identification of 13 possible HRT-specific Community State Types (CSTs), which appear to be specific to each anatomical region of the respiratory tract. Furthermore, functional characterization of the metagenomic datasets revealed specific microbial metabolic features correlating with the different compartments of the respiratory tract.

Conclusion: The meta-analysis here performed suggested that the variable presence of certain bacterial species seems to be linked to a location-related abundance gradient in the HRT and seems to be characterized by a specific microbial metabolic capability.

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