The Research Progress of Exosomes in Osteoarthritis, With Particular Emphasis on the Therapeutic Effect

Overview

Journal Front Pharmacol

Date 2022 Mar 21

PMID 35308214

Authors

Shang Xian Bo

Wang Chen

Liu Chang

Yu Hao Ran

Guo Hui Hui

Zhu Ya Kun

Xie Wu Kun

Fan Hai Tao

Cheng Wen Dan

Affiliations

Soon will be listed here.

Abstract

Exosomes participate in many physiological and pathological processes by regulating cell-to-cell communication. This affects the etiology and development of diseases, such as osteoarthritis (OA). Although exosomes in the OA tissue microenvironment are involved in the progression of OA, exosomes derived from therapeutic cells represent a new therapeutic strategy for OA treatment. Recent studies have shown that exosomes participate in OA treatment by regulating the proliferation, apoptosis, inflammation, and extracellular matrix synthesis of chondrocytes. However, studies in this field are scant. This review summarizes the therapeutic properties of exosomes on chondrocytes in OA and their underlying molecular mechanisms. We also discuss the challenges and prospects of exosome-based OA treatment.

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