Iron-catalyzed Intermolecular Cross-dehydrogenative C(sp)-H/C(sp)-H Coupling of Pyrimidine Bearing 4-thiazolidinones with Terminal Alkynes

Overview

Journal Mol Divers

Date 2022 Mar 21

PMID 35307757

Authors

Mayur I Morja

Kishor H Chikhalia

Affiliations

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Abstract

A novel, simple and efficient protocol for the Fe-catalyzed, intermolecular cross-dehydrogenative coupling of pyrimidine bearing 4-thiazolidinones systems and terminal alkynes was established. This methodology offers a high yielding, straightforward, and one-pot approach towards the synthesis of alkynylated 4-thiazolidinones without prior activation of C(sp)-H and C(sp)-H. The results of control experiments indicated that this conversion might proceed via a radical process.

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