The Comparison of Curcuminoid Formulations or Its Combination with Conventional Therapies Versus Conventional Therapies Alone for Knee Osteoarthritis

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2022 Mar 16

PMID 35294665

Authors

Yingying Wan

Wenting Sun

Jiaxi Yang

Jianxun Ren

Qiuai Kou

Affiliations

Soon will be listed here.

Abstract

Background: Presently, curcuminoid formulations or its combination with conventional therapies has been used for the treatment of knee osteoarthritis (KOA). Nevertheless, evidence is limited due to small-sized clinical trials. This study aims to evaluate the efficacy of curcuminoid formulations or its combination with conventional therapies for KOA.

Methods: Randomized controlled trials comparing curcuminoid formulations or its combination with conventional therapies versus conventional therapies, such as non-steroidal antiinflammatory drugs (NSAIDs) and chondroitin sulfate/glucosamine, were searched from databases.

Results: In total, 14 studies involving 1533 patients were included. Curcuminoid formulations were comparative to NSAIDs in reducing Visual Analogue Scale (VAS), total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and WOMAC score for pain/stiffness/physical function. No significant difference was seen between the two groups in terms of patients' satisfaction index, patients' global assessment, reduction of several inflammatory factor, rate of drug compliance, and rescue medication. Notably, curcuminoid formulations combined with NSAIDs significantly reduced VAS and WOMAC/Knee injury and OA Outcome Score (KOOS) pain score more than NSAIDs did. In addition, the curcuminoid formulations were superior to chondroitin sulfate/glucosamine in reducing VAS, total WOMAC score, and WOMAC score for stiffness/difficulty in physical function, while no significant difference was seen in reducing WOMAC pain score and Karnofsky Performance Scale score.

Conclusions: Curcuminoid formulations may be considered a promising alternative for treating KOA. Key points • Curcuminoid formulations are comparative to NSAIDs for KOA. • Curcuminoid formulations are superior to chondroitin sulfate/glucosamine for KOA. • Curcuminoid formulations could provide additional benefits in alleviating pain and some adverse events caused by NSAIDs.

Citing Articles

Curcuma as an anti-inflammatory component in treating osteoarthritis.

Djukic Koroljevic Z, Jordan K, Ivkovic J, Bender D, Peric P Rheumatol Int. 2022; 43(4):589-616.

PMID: 36394597 DOI: 10.1007/s00296-022-05244-8.

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