Metabolomics Analysis of Three Artemisia Species in the Tibet Autonomous Region of China

Overview

Journal BMC Plant Biol

Publisher Biomed Central

Specialty Biology

Date 2022 Mar 16

PMID 35291945

Authors

Xinyu Liu

Jinglong Wang

Enxia Huang

Bo Li

Shuhang Zhang

Weina Wang

Ziyu Guo

Kexin Wu

Yunhao Zhang

Baoyu Zhao

Hao Lu

Affiliations

Soon will be listed here.

Abstract

Background: The Artemisia species are widely distributed around the world, and have found important usage in traditional medicinal practice. This study was designed to investigate the metabolites of Tibetan Artemisia species and understand the metabolic pathways.

Methods: The metabolites from three Artemisia species in Tibet, were analyzed using LC-MS/MS. The differential metabolites were classified and analyzed by principal component analysis (PCA), partial least squares analysis and hierarchical clustering. KEGG Pathway enrichment analysis was used to identify the key metabolic pathways involved in the differential metabolites of three Artemisia species.

Result: The metabolites of three Artemisia species were analyzed. Under the positive ion mode in LC-MS/MS, 262 distinct metabolites were differentially detected from Artemisia sieversiana and Artemisia annua, 312 differential metabolites were detected from Artemisia wellbyi and Artemisia sieversiana, 306 differential metabolites were screened from Artemisia wellbyi and Artemisia annua. With the negative ion mode, 106 differential metabolites were identified from Artemisia sieversiana and Artemisia annua, 131 differential metabolites were identified from Artemisia wellbyi and Artemisia sieversiana,133 differential metabolites were differentially detected from Artemisia wellbyi and Artemisia annua. The selected differential metabolites were mainly organic acids and their derivatives, ketones, phenols, alcohols and coumarins. Among these natural compounds, artemisinin, has the highest relative content in Artemisia annua.

Conclusions: This is the first reported attempt to comparatively determine the types of the metabolites of the three widely distributed Artemisia species in Tibet. The information should help medicinal research and facilitate comprehensive development and utilization of Artemisia species in Tibet.

Citing Articles

Metabolomic analysis and antibacterial and antioxidant activities of three species of Artemisia plants in Tibet.

Liu X, Renzengwangdui , Tang S, Zhu Y, Wang M, Cao B BMC Plant Biol. 2023; 23(1):208.

PMID: 37081377 PMC: 10120219. DOI: 10.1186/s12870-023-04219-6.

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