Synthesis, α-glucosidase Inhibition, α-amylase Inhibition, and Molecular Docking Studies of 3,3-di(indolyl)indolin-2-ones

Overview

Journal Heliyon

Specialty Social Sciences

Date 2022 Mar 15

PMID 35287328

Authors

Mardi Santoso

Li Lin Ong

Nur Pasca Aijijiyah

First Ambar Wati

Azminah Azminah

Rose Malina Annuur

Arif Fadlan

Zaher M A Judeh

Affiliations

Soon will be listed here.

Abstract

The synthesized 3,3-di(indolyl)indolin-2-ones - showed desired higher α-glucosidase inhibitory activities and lower α-amylase inhibitory activities than standard drug acarbose. Particularly, compound showed favorable higher α-glucosidase % inhibition of 67 ± 13 and lower α-amylase % inhibition of 51 ± 4 in comparison to acarbose with % inhibition activities of 19 ± 5 and 90 ± 2, respectively. Docking studies of selected 3,3-di(indolyl)indolin-2-ones revealed key interactions with the active sites of both α-glucosidase and α-amylase, further supporting the observed % inhibitory activities. Furthermore, the binding energies are consistent with the % inhibition values. The results suggest that 3,3-di(indolyl)indolin-2-ones may be developed as suitable Alpha Glucosidase Inhibitors (AGIs) and the lower α-amylase activities should be advantageous to reduce the side effects exhibited by commercial AGIs.

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