Volumetric Directional Optical Coherence Tomography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2022 Mar 14

PMID 35284155

Authors

Shuibin Ni

Shanjida Khan

Thanh-Tin P Nguyen

Ringo Ng

Brandon J Lujan

Ou Tan

David Huang

Yifan Jian

Affiliations

Soon will be listed here.

Abstract

Photoreceptor loss and resultant thinning of the outer nuclear layer (ONL) is an important pathological feature of retinal degenerations and may serve as a useful imaging biomarker for age-related macular degeneration. However, the demarcation between the ONL and the adjacent Henle's fiber layer (HFL) is difficult to visualize with standard optical coherence tomography (OCT). A dedicated OCT system that can precisely control and continuously and synchronously update the imaging beam entry points during scanning has not been realized yet. In this paper, we introduce a novel imaging technology, Volumetric Directional OCT (VD-OCT), which can dynamically adjust the incident beam on the pupil without manual adjustment during a volumetric OCT scan. We also implement a customized spoke-circular scanning pattern to observe the appearance of HFL with sufficient optical contrast in continuous cross-sectional scans through the entire volume. The application of VD-OCT for retinal imaging to exploit directional reflectivity properties of tissue layers has the potential to allow for early identification of retinal diseases.

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