Molecular Characterization of High-risk Humanpapillomavirus Genotypes in Women with or Without Cervical Lesions at VIA/VILI in Kara, Togo

Overview

Journal Afr Health Sci

Date 2022 Mar 14

PMID 35283946

Authors

Essolakina Dolou

Akouele Kuassi-Kpede

Theodora M Zohoncon

Ina Marie Traore

Gnatoulma Katawa

Alice R Ouedraogo

Esther Mah Traore

Prosper Bado

Clarisse T Ouedraogo

Florencia Djigma

Abdoul-Samadou Aboubakari

Simplice Damintoti Karou

Jacques Simpore

Affiliations

Soon will be listed here.

Abstract

Background: Persistent infection with high-risk (HR) papillomavirus (HPV) genotypes plays a central role in the pathogenesis of invasive cervical cancer.

Objectives: This study aimed to determine the prevalence and distribution of HR-HPV among women with or without cervical lesions at VIA/VILI in Togo.

Methods: Cervical samples were collected from 238 women with or without cervical lesions at VIA / VILI and[c3] DNA [c4]was extracted and analyzed by real-time multiplex PCR. Logistic regression analysis was used to determined risk factors associated with HPV infection.inPietro Annigoni Biomolecular Research Center (CERBA / LABIOGENE) in Burkina Faso.

Results: The age of the women ranged from 17 to 61 years old, and most were married (73.5%). The prevalence of HRHPV was 35.71% and this was higher in the age range 35-39 years. The six most common genotypes were HPV 31 (18.7%), HPV 52 (13.82%), HPV 68 (13.01%), HPV 66 (9.76%), HPV 58 (8.13%) and HPV 56 (8.13%). Genotypes HPV 18 (4.07%) and HPV 16 (0.81%) were less frequent.[c5] Married or living with a partner was associated with HPV infection (OR=2,17, IC [1.20-3.91], p<0,009).

Conclusion: This study allowed characterizing for the first time in Togo, HR-HPV genotypes. This will help mapping-HR-HPV genotypes circulating in West Africa.

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