MYCT1 Alters the Glycogen Shunt by Regulating Selective Translation of RACK1-mediated Enzymes

Overview

Journal iScience

Publisher Cell Press

Date 2022 Mar 14

PMID 35281731

Authors

Dong-Xue Ding

Yue Wang

Wei Yan

Wei-Neng Fu

Affiliations

Soon will be listed here.

Abstract

MYCT1 has been shown to function as a tumor suppressor in various tumors, but its role in metabolism has never been reported. Here, we showed that global inactivation of Myct1 in mice led to progressive accumulation of glycogen in the liver, which was accompanied by aberrant changes in intermediates of the glycogen metabolic pathway. Mechanistically, MYCT1 appeared to promote translation efficiency of PGM1, UGP2 and GSK3A in hepatic cells in a RACK1-dependent manner. Consequently, upregulation of the three enzymes enhanced the glycogen shunt. Our data reveal a critical role of MYCT1 as a switch for the glycogen shunt in tumor cells.

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