» Articles » PMID: 35280885

Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report

Overview
Specialty General Medicine
Date 2022 Mar 14
PMID 35280885
Authors
Affiliations
Soon will be listed here.
Abstract

Mucormycosis is a rare and invasive fungal infection with high mortality. Cases of invasive pulmonary mucormycosis that involve allergic reactions such as allergic bronchopulmonary mycosis are rarely reported. Herein, we describe a case of invasive pulmonary mucormycosis overlapping with allergic diseases in a patient who presented with eosinophilia and high total plasma immunoglobulin E (IgE). The patient was successfully treated with systemic corticosteroids (initial dose of prednisolone approximately 0.5 mg/kg per day, total duration less than 3 months) combined with posaconazole antifungal therapy. The treatment resulted in recovery of peripheral-blood eosinophil count and total plasma IgE, and significant reduction in lung lesions. A subsequent lobectomy was performed. The findings in this case indicate that systemic corticosteroid therapy may contribute to the treatment of pulmonary mucormycosis combined with allergic factors.

Citing Articles

Case report: Disseminated mucormycosis misdiagnosed as malignancy developed from allergic bronchopulmonary mycosis caused by following SARS-CoV-2 infection in a woman.

Kong C, Zong L, Ji S, Liu Y, Li M Front Med (Lausanne). 2024; 11:1394500.

PMID: 38988360 PMC: 11233786. DOI: 10.3389/fmed.2024.1394500.

References
1.
Yeoh D, Saunders T, Butters C, Burgner D, Bryant P, Cain T . Refractory thoracic conidiobolomycosis treated with mepolizumab immunotherapy. J Allergy Clin Immunol Pract. 2021; 9(6):2527-2530.e6. DOI: 10.1016/j.jaip.2021.01.044. View

2.
Agarwal R, Aggarwal A, Dhooria S, Sehgal I, Garg M, Saikia B . A randomised trial of glucocorticoids in acute-stage allergic bronchopulmonary aspergillosis complicating asthma. Eur Respir J. 2015; 47(2):490-8. DOI: 10.1183/13993003.01475-2015. View

3.
Sato M, Gemma H, Sano T, Ono T, ATSUMI E, Ito I . [Pulmonary mucormycosis caused by Cunninghamella bertholletiae in a non-immunocompromised woman]. Nihon Kokyuki Gakkai Zasshi. 2002; 39(10):758-62. View

4.
Obar J, Carvalho A, Vitte J, Ranque S . Editorial: Host and Pathogen Determinants of Allergic and Invasive Fungal Diseases. Front Immunol. 2020; 11:856. PMC: 7205003. DOI: 10.3389/fimmu.2020.00856. View

5.
Nucci M, Engelhardt M, Hamed K . Mucormycosis in South America: A review of 143 reported cases. Mycoses. 2019; 62(9):730-738. PMC: 6852100. DOI: 10.1111/myc.12958. View