The Interaction Between Nanoparticles and Immune System: Application in the Treatment of Inflammatory Diseases

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2022 Mar 13

PMID 35279135

Authors

Jin Liu

Zeyang Liu

Yan Pang

Huifang Zhou

Affiliations

Soon will be listed here.

Abstract

Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of different materials and adjustment of their physical and chemical properties, nanoparticles can have diverse effects on the organism and may change the treating paradigm of multiple diseases in the future. More and more results show that nanoparticles can function as immunomodulators and some formulas have been approved for the treatment of inflammation-related diseases. However, our current understanding of the mechanisms that nanoparticles can influence immune responses is still limited, and systemic clinical trials are necessary for the evaluation of their security and long-term effects. This review provides an overview of the recent advances in nanoparticles that can interact with different cellular and molecular components of the immune system and their application in the management of inflammatory diseases, which are caused by abnormal immune reactions. This article focuses on the mechanisms of interaction between nanoparticles and the immune system and tries to provide a reference for the future design of nanotechnology for the treatment of inflammatory diseases.

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References

Aratani Y . Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function. Arch Biochem Biophys. 2018; 640:47-52. DOI: 10.1016/j.abb.2018.01.004. View

Ginhoux F, Guilliams M . Tissue-Resident Macrophage Ontogeny and Homeostasis. Immunity. 2016; 44(3):439-449. DOI: 10.1016/j.immuni.2016.02.024. View

Heidt T, Sager H, Courties G, Dutta P, Iwamoto Y, Zaltsman A . Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014; 20(7):754-758. PMC: 4087061. DOI: 10.1038/nm.3589. View

Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R . Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2020; 20(2):101-124. PMC: 7717100. DOI: 10.1038/s41573-020-0090-8. View

Carnasciali A, Amoriello R, Bonechi E, Mazzoni A, Ravagli C, Doumett S . T Cell Delivery of Nanoparticles-Bound Anti-CD20 Monoclonal Antibody: Successful B Cell Depletion in the Spinal Cord during Experimental Autoimmune Encephalomyelitis. J Neuroimmune Pharmacol. 2020; 16(2):376-389. DOI: 10.1007/s11481-020-09931-w. View

Chu D, Dong X, Shi X, Zhang C, Wang Z . Neutrophil-Based Drug Delivery Systems. Adv Mater. 2018; 30(22):e1706245. PMC: 6161715. DOI: 10.1002/adma.201706245. View

Polak R, Lim R, Beppu M, Pitombo R, Cohen R, Rubner M . Liposome-Loaded Cell Backpacks. Adv Healthc Mater. 2015; 4(18):2832-41. DOI: 10.1002/adhm.201500604. View

Thomas T, Goonewardena S, Majoros I, Kotlyar A, Cao Z, Leroueil P . Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis. Arthritis Rheum. 2011; 63(9):2671-80. PMC: 3168725. DOI: 10.1002/art.30459. View

Borregaard N . Neutrophils, from marrow to microbes. Immunity. 2010; 33(5):657-70. DOI: 10.1016/j.immuni.2010.11.011. View

10.

Haycook C, Balsamo J, Glass E, Williams C, Hong C, Major A . PEGylated PLGA Nanoparticle Delivery of Eggmanone for T Cell Modulation: Applications in Rheumatic Autoimmunity. Int J Nanomedicine. 2020; 15:1215-1228. PMC: 7036983. DOI: 10.2147/IJN.S234850. View

11.

Hashimoto D, Chow A, Noizat C, Teo P, Beasley M, Leboeuf M . Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity. 2013; 38(4):792-804. PMC: 3853406. DOI: 10.1016/j.immuni.2013.04.004. View

12.

Deng Z, Rong Y, Teng Y, Mu J, Zhuang X, Tseng M . Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase. Mol Ther. 2017; 25(7):1641-1654. PMC: 5498816. DOI: 10.1016/j.ymthe.2017.01.025. View

13.

Liu Y, Ai K, Ji X, Askhatova D, Du R, Lu L . Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke. J Am Chem Soc. 2016; 139(2):856-862. PMC: 5752099. DOI: 10.1021/jacs.6b11013. View

14.

Netea M, Schlitzer A, Placek K, Joosten L, Schultze J . Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens. Cell Host Microbe. 2019; 25(1):13-26. DOI: 10.1016/j.chom.2018.12.006. View

15.

Miao X, Leng X, Zhang Q . The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research. Int J Mol Sci. 2017; 18(2). PMC: 5343871. DOI: 10.3390/ijms18020336. View

16.

Duivenvoorden R, Tang J, Cormode D, Mieszawska A, Izquierdo-Garcia D, Ozcan C . A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. Nat Commun. 2014; 5:3065. PMC: 4001802. DOI: 10.1038/ncomms4065. View

17.

Natoli G, Ostuni R . Adaptation and memory in immune responses. Nat Immunol. 2019; 20(7):783-792. DOI: 10.1038/s41590-019-0399-9. View

18.

Locati M, Curtale G, Mantovani A . Diversity, Mechanisms, and Significance of Macrophage Plasticity. Annu Rev Pathol. 2019; 15:123-147. PMC: 7176483. DOI: 10.1146/annurev-pathmechdis-012418-012718. View

19.

Ahrens E, Bulte J . Tracking immune cells in vivo using magnetic resonance imaging. Nat Rev Immunol. 2013; 13(10):755-63. PMC: 3886235. DOI: 10.1038/nri3531. View

20.

Bacci M, Capobianco A, Monno A, Cottone L, Di Puppo F, Camisa B . Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease. Am J Pathol. 2009; 175(2):547-56. PMC: 2716955. DOI: 10.2353/ajpath.2009.081011. View